V1-VASCULAR VASOPRESSIN RECEPTORS OF MESANGIAL CELL
V1-VASCULAR VASOPRESSIN RECEPTORS OF MESANGIAL CELL
批准号:
3900848
负责人:
MARC THIBONNIER
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
affinity chromatography angiotensin /renin /aldosterone hypertension arginine vasopressin biological signal transduction calcium flux hormone receptor hormone regulation /control mechanism human tissue ion transport kidney cell laboratory rat molecular cloning monoclonal antibody platelets protein purification receptor binding renal glomerulus spontaneous hypertensive rat tissue /cell culture vascular resistance vasomotion
中文摘要
血管加压素(AVP)不仅是一种有效的抗利尿剂和血管收缩剂
英文摘要
Vasopressin (AVP) is not only a potent antidiuretic and vasoconstrictor
hormone but it also stimulates platelet aggregation, blood coagulation
factors production, glucose release and fibroblast proliferation. All
these actions may mediate the involvement of AVP in the development of
arterial hypertension and atherosclerosis, the leading causes of human
mortality.
The long-term objectives of our research dedicated to AVP are: 1) to
delineate the role played by AVP in the development of arterial
hypertensin (HTA) and atherosclerosis, 2) to purify and clone AVP
receptors in order to: a) design non peptide orally active AVP
antagonists to be used in diseases characterized by AVP-induced
alterations of blood volume, blood pressure, and blood coagulation, b)
identify the molecular defect underlying the resistance to the
peripheral actions of AVP in the nephrogenic type of diabetes insipidus.
Using human and rat glomerular mesangial cells (GMC) in culture, the
goals of the present proposal are to: 1) explore the complete cascade
of events following binding of AVP to its specific membrane V1-vascular
receptors and isolate any alteration explaining the increased vascular
reactivity to AVP noted in genetically and DOCA-salt hypertensive rats.
2) purify the human and rat V1-vascular AVP receptors.
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会议论文
PREVENTION OF CARDIOVASCULAR DISEASE IN DIABETES MELLITU
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批准号:6191628
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项目类别:
-
资助金额:$62.65万
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财政年份:1999
-
负责人:MARC THIBONNIER
-
依托单位:
PREVENTION OF CARDIOVASCULAR DISEASE IN DIABETES MELLITU
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批准号:6358398
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项目类别:
-
资助金额:$183.32万
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财政年份:1999
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负责人:MARC THIBONNIER
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依托单位:
V1-VASCULAR VASOPRESSIN RECEPTORS OF MESANGIAL CELL
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批准号:6109948
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项目类别:
-
资助金额:$0.0万
-
财政年份:1998
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负责人:MARC THIBONNIER
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依托单位:
VPA985 IN HYPONATREMIA DUE TO INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION
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批准号:6115286
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项目类别:
-
资助金额:$1.92万
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财政年份:1998
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负责人:MARC THIBONNIER
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依托单位:
OPC 41061 IN HOSPITALIZED PATIENTS W/ HYPONATREMIA
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批准号:6264424
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项目类别:
-
资助金额:$1.92万
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财政年份:1998
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负责人:MARC THIBONNIER
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依托单位:
VPA985 IN HYPONATREMIA DUE TO INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION
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批准号:6276520
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项目类别:
-
资助金额:$1.83万
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财政年份:1997
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负责人:MARC THIBONNIER
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依托单位:
V1-VASCULAR VASOPRESSIN RECEPTORS OF MESANGIAL CELL
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批准号:6242032
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项目类别:
-
资助金额:$22.19万
-
财政年份:1997
-
负责人:MARC THIBONNIER
-
依托单位:
VPA985 IN HYPONATREMIA DUE TO INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION
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批准号:6246458
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项目类别:
-
资助金额:$1.98万
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财政年份:1997
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负责人:MARC THIBONNIER
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依托单位:
ANTIHYPERTENSIVE ACTIVITY OF SR49059 IN HYPERTENSION IN TWO ETHNICITIES
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批准号:6246433
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项目类别:
-
资助金额:$1.98万
-
财政年份:1997
-
负责人:MARC THIBONNIER
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依托单位:
VPA-985 IN PATIENTS WITH HYPONATREMIA
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批准号:6276556
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项目类别:
-
资助金额:$1.83万
-
财政年份:1997
-
负责人:MARC THIBONNIER
-
依托单位:
VPA985 IN HYPONATREMIA DUE TO INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION
-
批准号:6305439
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项目类别:
-
资助金额:$1.92万
-
财政年份:--
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负责人:MARC THIBONNIER
-
依托单位:
OPC 41061 IN HOSPITALIZED PATIENTS W/ HYPONATREMIA
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批准号:6305364
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项目类别:
-
资助金额:$1.92万
-
财政年份:--
-
负责人:MARC THIBONNIER
-
依托单位:
ANTIHYPERTENSIVE ACTIVITY OF SR49059 IN HYPERTENSION IN TWO ETHNICITIES
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批准号:5219150
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项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:MARC THIBONNIER
-
依托单位:--
V1-VASCULAR VASOPRESSIN RECEPTORS OF MESANGIAL CELL
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批准号:5213733
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项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:MARC THIBONNIER
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依托单位:--
V1-VASCULAR VASOPRESSIN RECEPTORS OF MESANGIAL CELL
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批准号:3758703
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:MARC THIBONNIER
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依托单位:
V1-VASCULAR VASOPRESSIN RECEPTORS OF MESANGIAL CELL
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批准号:3736709
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:MARC THIBONNIER
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依托单位:
V1-VASCULAR VASOPRESSIN RECEPTORS OF MESANGIAL CELL
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批准号:3880639
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项目类别:
-
资助金额:$0.0万
-
财政年份:--
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负责人:MARC THIBONNIER
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依托单位:
V1-VASCULAR VASOPRESSIN RECEPTORS OF MESANGIAL CELL
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批准号:3780721
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:MARC THIBONNIER
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依托单位:
VPA-985 IN PATIENTS WITH HYPONATREMIA
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批准号:6115322
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项目类别:
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资助金额:$2.33万
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财政年份:--
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负责人:MARC THIBONNIER
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依托单位:
V1-VASCULAR VASOPRESSIN RECEPTORS OF MESANGIAL CELL
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批准号:3859573
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:MARC THIBONNIER
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依托单位: