V1-VASCULAR VASOPRESSIN RECEPTORS OF MESANGIAL CELL
V1-VASCULAR VASOPRESSIN RECEPTORS OF MESANGIAL CELL
批准号:
3900848
负责人:
MARC THIBONNIER
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
affinity chromatography angiotensin /renin /aldosterone hypertension arginine vasopressin biological signal transduction calcium flux hormone receptor hormone regulation /control mechanism human tissue ion transport kidney cell laboratory rat molecular cloning monoclonal antibody platelets protein purification receptor binding renal glomerulus spontaneous hypertensive rat tissue /cell culture vascular resistance vasomotion
中文摘要
加压素(AVP)不仅是一种强有力的抗利尿剂和血管收缩剂,
激素,但它也刺激血小板聚集,血液凝固
因子产生、葡萄糖释放和成纤维细胞增殖。 所有
这些作用可能介导AVP参与了
动脉高血压和动脉粥样硬化,人类的主要原因
mortality.
我们致力于AVP研究的长期目标是:
阐明AVP在动脉发育中的作用,
高血压(HTA)与动脉粥样硬化关系; 2)AVP的纯化和克隆
a)设计非肽口服活性AVP
用于特征为AVP诱导的疾病的拮抗剂
血容量、血压和血液凝固的改变,B)
确定耐药性背后的分子缺陷,
AVP在肾源性尿崩症中的外周作用
使用人和大鼠肾小球系膜细胞(GMC)培养,
本提案的目标是:1)探索完整的级联
AVP与其特异性膜V1-血管结合后的事件
受体和分离任何改变解释增加的血管
在遗传性和DOCA-盐高血压大鼠中观察到对AVP的反应性。
2)纯化人和大鼠V1血管AVP受体。
英文摘要
Vasopressin (AVP) is not only a potent antidiuretic and vasoconstrictor
hormone but it also stimulates platelet aggregation, blood coagulation
factors production, glucose release and fibroblast proliferation. All
these actions may mediate the involvement of AVP in the development of
arterial hypertension and atherosclerosis, the leading causes of human
mortality.
The long-term objectives of our research dedicated to AVP are: 1) to
delineate the role played by AVP in the development of arterial
hypertensin (HTA) and atherosclerosis, 2) to purify and clone AVP
receptors in order to: a) design non peptide orally active AVP
antagonists to be used in diseases characterized by AVP-induced
alterations of blood volume, blood pressure, and blood coagulation, b)
identify the molecular defect underlying the resistance to the
peripheral actions of AVP in the nephrogenic type of diabetes insipidus.
Using human and rat glomerular mesangial cells (GMC) in culture, the
goals of the present proposal are to: 1) explore the complete cascade
of events following binding of AVP to its specific membrane V1-vascular
receptors and isolate any alteration explaining the increased vascular
reactivity to AVP noted in genetically and DOCA-salt hypertensive rats.
2) purify the human and rat V1-vascular AVP receptors.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
PREVENTION OF CARDIOVASCULAR DISEASE IN DIABETES MELLITU
-
批准号:6191628
-
项目类别:
-
资助金额:$62.65万
-
财政年份:1999
-
负责人:MARC THIBONNIER
-
依托单位:
PREVENTION OF CARDIOVASCULAR DISEASE IN DIABETES MELLITU
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批准号:6358398
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项目类别:
-
资助金额:$183.32万
-
财政年份:1999
-
负责人:MARC THIBONNIER
-
依托单位:
V1-VASCULAR VASOPRESSIN RECEPTORS OF MESANGIAL CELL
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批准号:6109948
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项目类别:
-
资助金额:$0.0万
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财政年份:1998
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负责人:MARC THIBONNIER
-
依托单位:
VPA985 IN HYPONATREMIA DUE TO INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION
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批准号:6115286
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项目类别:
-
资助金额:$1.92万
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财政年份:1998
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负责人:MARC THIBONNIER
-
依托单位:
OPC 41061 IN HOSPITALIZED PATIENTS W/ HYPONATREMIA
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批准号:6264424
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项目类别:
-
资助金额:$1.92万
-
财政年份:1998
-
负责人:MARC THIBONNIER
-
依托单位:
V1-VASCULAR VASOPRESSIN RECEPTORS OF MESANGIAL CELL
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批准号:6242032
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项目类别:
-
资助金额:$22.19万
-
财政年份:1997
-
负责人:MARC THIBONNIER
-
依托单位:
VPA985 IN HYPONATREMIA DUE TO INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION
-
批准号:6276520
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项目类别:
-
资助金额:$1.83万
-
财政年份:1997
-
负责人:MARC THIBONNIER
-
依托单位:
VPA985 IN HYPONATREMIA DUE TO INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION
-
批准号:6246458
-
项目类别:
-
资助金额:$1.98万
-
财政年份:1997
-
负责人:MARC THIBONNIER
-
依托单位:
ANTIHYPERTENSIVE ACTIVITY OF SR49059 IN HYPERTENSION IN TWO ETHNICITIES
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批准号:6246433
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项目类别:
-
资助金额:$1.98万
-
财政年份:1997
-
负责人:MARC THIBONNIER
-
依托单位:
VPA-985 IN PATIENTS WITH HYPONATREMIA
-
批准号:6276556
-
项目类别:
-
资助金额:$1.83万
-
财政年份:1997
-
负责人:MARC THIBONNIER
-
依托单位:
VPA985 IN HYPONATREMIA DUE TO INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION
-
批准号:6305439
-
项目类别:
-
资助金额:$1.92万
-
财政年份:--
-
负责人:MARC THIBONNIER
-
依托单位:
OPC 41061 IN HOSPITALIZED PATIENTS W/ HYPONATREMIA
-
批准号:6305364
-
项目类别:
-
资助金额:$1.92万
-
财政年份:--
-
负责人:MARC THIBONNIER
-
依托单位:
ANTIHYPERTENSIVE ACTIVITY OF SR49059 IN HYPERTENSION IN TWO ETHNICITIES
-
批准号:5219150
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项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:MARC THIBONNIER
-
依托单位:--
V1-VASCULAR VASOPRESSIN RECEPTORS OF MESANGIAL CELL
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批准号:5213733
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项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:MARC THIBONNIER
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依托单位:--
V1-VASCULAR VASOPRESSIN RECEPTORS OF MESANGIAL CELL
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批准号:3736709
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:MARC THIBONNIER
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依托单位:
V1-VASCULAR VASOPRESSIN RECEPTORS OF MESANGIAL CELL
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批准号:3758703
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:MARC THIBONNIER
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依托单位:
V1-VASCULAR VASOPRESSIN RECEPTORS OF MESANGIAL CELL
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批准号:3880639
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:MARC THIBONNIER
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依托单位:
V1-VASCULAR VASOPRESSIN RECEPTORS OF MESANGIAL CELL
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批准号:3780721
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:MARC THIBONNIER
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依托单位:
V1-VASCULAR VASOPRESSIN RECEPTORS OF MESANGIAL CELL
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批准号:3859573
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:MARC THIBONNIER
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依托单位:
VPA-985 IN PATIENTS WITH HYPONATREMIA
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批准号:6115322
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项目类别:
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资助金额:$2.33万
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财政年份:--
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负责人:MARC THIBONNIER
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依托单位: