VPA985 IN HYPONATREMIA DUE TO INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION
VPA985 IN HYPONATREMIA DUE TO INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION
批准号:
6276520
负责人:
MARC THIBONNIER
金额:
$1.83万
依托单位国家:
美国
项目类别:
财政年份:
1997
资助国家:
美国
项目状态:
已结题
起止时间:
1997-12-01 至 1998-11-30
中文摘要
抗利尿激素血管加压素(AVP)是一种肽激素
英文摘要
Vasopressin (AVP), the antidiuretic hormone is a peptide hormone
actively involved in the regulation of body fluid osmolality, blood
volume, blood pressure, and cell proliferation via the stimulation of
specific membrane-bound receptors classified into V1a-vascular, V2-
renal, and V3-pituitary subtypes having distinct pharmacological
profiles and intracellular second messengers.
The secretion of AVP is an absolute requirement for the maintenance of
fluid homeostasis as shown in human and experimental models of diabetes
insipidus. The usefulness of natriuretic agents has been demonstrated
in conditions associated with water and salt retention. However, there
are diseases (hyponatremia of congestive heart failure, liver cirrhosis,
nephrotic syndrome, and the syndrome of inappropriate secretion of
antidiuretic hormone, SIADH) due to the inappropriate release of
vasopressin and characterized by an excess retention of water. An agent
that increases urine output by producing a free water diuresis would be
of significant advantage in these conditions.
This study is designed to evaluate the efficacy, safety, and tolerance
of a single oral dose of VPA-985 in patients with hyponatremia due to
SIADH. In addition, preliminary pharmacokinetic and pharmacodynamic
parameters will be assessed. This study has just begun patient
recruitment. Four to six patients with diagnosed SIADH between the ages
of 18 and 75 years will be enrolled at this site.
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PREVENTION OF CARDIOVASCULAR DISEASE IN DIABETES MELLITU
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批准号:6191628
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项目类别:
-
资助金额:$62.65万
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财政年份:1999
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负责人:MARC THIBONNIER
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依托单位:
PREVENTION OF CARDIOVASCULAR DISEASE IN DIABETES MELLITU
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批准号:6358398
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项目类别:
-
资助金额:$183.32万
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财政年份:1999
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负责人:MARC THIBONNIER
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依托单位:
V1-VASCULAR VASOPRESSIN RECEPTORS OF MESANGIAL CELL
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批准号:6109948
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项目类别:
-
资助金额:$0.0万
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财政年份:1998
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负责人:MARC THIBONNIER
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依托单位:
VPA985 IN HYPONATREMIA DUE TO INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION
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批准号:6115286
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项目类别:
-
资助金额:$1.92万
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财政年份:1998
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负责人:MARC THIBONNIER
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依托单位:
OPC 41061 IN HOSPITALIZED PATIENTS W/ HYPONATREMIA
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批准号:6264424
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项目类别:
-
资助金额:$1.92万
-
财政年份:1998
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负责人:MARC THIBONNIER
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依托单位:
V1-VASCULAR VASOPRESSIN RECEPTORS OF MESANGIAL CELL
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批准号:6242032
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项目类别:
-
资助金额:$22.19万
-
财政年份:1997
-
负责人:MARC THIBONNIER
-
依托单位:
VPA985 IN HYPONATREMIA DUE TO INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION
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批准号:6246458
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项目类别:
-
资助金额:$1.98万
-
财政年份:1997
-
负责人:MARC THIBONNIER
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依托单位:
ANTIHYPERTENSIVE ACTIVITY OF SR49059 IN HYPERTENSION IN TWO ETHNICITIES
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批准号:6246433
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项目类别:
-
资助金额:$1.98万
-
财政年份:1997
-
负责人:MARC THIBONNIER
-
依托单位:
VPA-985 IN PATIENTS WITH HYPONATREMIA
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批准号:6276556
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项目类别:
-
资助金额:$1.83万
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财政年份:1997
-
负责人:MARC THIBONNIER
-
依托单位:
V1-VASCULAR VASOPRESSIN RECEPTORS OF MESANGIAL CELL
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批准号:3900848
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项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:MARC THIBONNIER
-
依托单位:
V1-VASCULAR VASOPRESSIN RECEPTORS OF MESANGIAL CELL
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批准号:5213733
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项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:MARC THIBONNIER
-
依托单位:--
ANTIHYPERTENSIVE ACTIVITY OF SR49059 IN HYPERTENSION IN TWO ETHNICITIES
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批准号:5219150
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项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:MARC THIBONNIER
-
依托单位:--
VPA985 IN HYPONATREMIA DUE TO INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION
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批准号:6305439
-
项目类别:
-
资助金额:$1.92万
-
财政年份:--
-
负责人:MARC THIBONNIER
-
依托单位:
OPC 41061 IN HOSPITALIZED PATIENTS W/ HYPONATREMIA
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批准号:6305364
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项目类别:
-
资助金额:$1.92万
-
财政年份:--
-
负责人:MARC THIBONNIER
-
依托单位:
V1-VASCULAR VASOPRESSIN RECEPTORS OF MESANGIAL CELL
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批准号:3736709
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项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:MARC THIBONNIER
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依托单位:
V1-VASCULAR VASOPRESSIN RECEPTORS OF MESANGIAL CELL
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批准号:3758703
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:MARC THIBONNIER
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依托单位:
V1-VASCULAR VASOPRESSIN RECEPTORS OF MESANGIAL CELL
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批准号:3880639
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项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:MARC THIBONNIER
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依托单位:
V1-VASCULAR VASOPRESSIN RECEPTORS OF MESANGIAL CELL
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批准号:3780721
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:MARC THIBONNIER
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依托单位:
V1-VASCULAR VASOPRESSIN RECEPTORS OF MESANGIAL CELL
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批准号:3859573
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:MARC THIBONNIER
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依托单位:
VPA-985 IN PATIENTS WITH HYPONATREMIA
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批准号:6115322
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项目类别:
-
资助金额:$2.33万
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财政年份:--
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负责人:MARC THIBONNIER
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依托单位:
海外基金