Brain connectome: from synapse, large-scale network to behaviour

大脑连接组：从突触、大规模网络到行为

• 批准号: DP180103319
• 负责人: Prof Pankaj Sah
• 金额: $ 25.23万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-03-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP180103319
• 关键词: Brain; connectome; synapse; large; scale

This project aims to investigate how behaviour shapes the large-scale network synchrony by determination of task-specific networks using whole-brain resting-state functional Magnetic Resonance Imaging (MRI) and its relationship with synaptic plasticity. Enhanced synaptic connectivity has been suggested as a mechanism of memory but the system-level circuit dynamics in memory process are not clear. The outcome is anticipated to bridge the knowledge gap between brain and behaviour.

该项目旨在通过使用全脑静息状态功能磁共振成像（MRI）确定特定任务网络来研究行为如何塑造大规模网络同步性及其与突触可塑性的关系。增强的突触连接被认为是记忆的一种机制，但记忆过程中的系统级电路动力学尚不清楚。预计这一结果将弥合大脑和行为之间的知识鸿沟。