AIDS DEMENTIA COMPLEX IN HIV-SEROPOSITIVE GAY MEN

HIV 血清阳性男同性恋者的艾滋病痴呆症

• 批准号: 3923469
• 负责人: JOHN T. SIDTIS
• 金额: --
• 依托单位: MEMORIAL HOSPITAL FOR CANCER & ALLIED DI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3923469
• 关键词: AIDS; HIV infections; Retroviridae disease; blood chemistry; cerebrospinal fluid; computed axial tomography; dementia; disease /disorder proneness /risk; homosexuals; human immunodeficiency virus 1; human subject; immunologic techniques; magnetic resonance imaging; male; neuropsychological tests; neurotropic virus

This project proposes studies of HIV-seropositive individuals without AIDS who are at moderate risk for developing the ADC, along with a group of seronegative controls, in order to more precisely characterize the neurological and neuropsychological manifestations of this syndrome, as well as its immunological, virological and neuroradiological correlates, and its natural history. Clinical characterization will be accomplish by both cross-sectional and prospective/longitudinal studies to define the relative incidence, clinical presentation and evolution of the ADC. The neurological and neuropsychological data will then be correlated with systemic disease status, immunological function, virological findings in CSF and blood, and neuroradiological abnormalities including brain atrophy as and white matter changes revealed by magnetic resonance imaging (MRI). These studies will additionally contribute to refining neurological and neuropsychological instrumentation for evaluating the ADC. The data obtained in this Project will be combined with that derive from Projects 1 and 3, which examine individuals at different stages of HIV infection, in order to derive a broad picture of the evolution and natural history of the ADC.

该项目提议对艾滋病毒血清阳性个体进行研究 没有 AIDS 且处于发展 ADC 中等风险的人，以及 与一组血清阴性对照，以便更准确地 描述神经学和神经心理学表现的特征 该综合征及其免疫学、病毒学和 神经放射学相关性及其自然史。 临床 表征将通过横截面和 前瞻性/纵向研究以确定相对发生率， ADC 的临床表现和演变。 神经科的 然后神经心理学数据将与系统相关 疾病状态、免疫功能、脑脊液病毒学检查结果 和血液以及神经放射学异常，包括大脑 磁共振显示萎缩和白质变化 成像（MRI）。 这些研究还将有助于 完善神经学和神经心理学仪器 评估 ADC。 本项目获得的数据将是 结合项目 1 和 3 的结果，检查 处于艾滋病毒感染不同阶段的个体， 得出进化和自然历史的广阔图景 ADC。