QUANTITATIVE PERFORMANCE ASSESSMENT OF THE AIDS DEMENTIA COMPLEX

艾滋病痴呆症的定量表现评估

• 批准号: 5215268
• 负责人: JOHN T. SIDTIS
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5215268
• 关键词: AIDS dementia complex; AIDS therapy; HIV infections; attention; audiometry; auditory stimulus; biomedical automation; brain electrical activity; cognition; computer program /software; disease /disorder classification; electroencephalography; evoked potentials; human subject; human therapy evaluation; method development; neuropsychological tests; neuropsychology; performance; psychomotor reaction time; stimulus /response; visual stimulus

This new project seeks to extend the work on neuropsychological assessment accomplished in the Program's initial period of funding. Its objective is to extend the current method of quantitative performance evaluation of ADC, focussing on more sensitive measures that might prove valuable in multidisciplinary studies directed at the underlying pathophysiological mechanism of ADC. Starting with a well-standardized procedure, this project will establish the utility of a Continuous Performance Task (CPT), using a reaction time measure of sustained attention to characterize ADC. The utility of CPT as a sensitive, early measure of treatment effects in studies of anti-retroviral therapy and of therapies directed at potential neuropathophysiological mechanisms of ADC will also be studied. As a correlate of the CPT measure, its corresponding event related potential (ERP) will also be studied with respect to ADC. Both the CPT and event related potential measures will be studied during FDG/PET scanning in collaboration with Project 4. The objective of these studies is not to replace the previously established methods of the neuropsychological assessment of ADC, but to develop more sensitive measures of impairment in this syndrome that can play a significant role in studying treatment effects and potential pathophysiological mechanisms. In the context of this Program, these studies will be integrated with the studies of regional cerebral metabolism, quantitative MRI, and EEG power spectra, and will play an important role in correlative studies using surrogate markers of direct and indirect effects of HIV-1 infection of the CNS.

这个新项目旨在扩展神经心理学方面的工作 评估是在该计划资助的初始阶段完成的。 它是 目标是扩展当前的定量绩效方法 ADC 的评估，重点关注可能证明的更敏感的措施 在针对基础的多学科研究中有价值 ADC的病理生理机制。 从良好的标准化开始 程序，该项目将建立一个连续的效用 绩效任务（CPT），使用持续的反应时间测量 注意表征 ADC。 CPT 作为一种敏感的早期治疗方法的实用性 抗逆转录病毒治疗研究中治疗效果的测量和 针对潜在神经病理生理机制的治疗方法 ADC也会被研究。 作为 CPT 衡量标准的相关因素，其 相应的事件相关电位（ERP）也将被研究 尊重ADC。 CPT 和事件相关的潜在措施都将 与项目 4 合作在 FDG/PET 扫描期间进行研究。 这些研究的目的不是要取代先前建立的 ADC 的神经心理学评估方法，但需要开发更多 对这种综合征的损伤进行敏感的测量，可以发挥作用 在研究治疗效果和潜力方面发挥着重要作用 病理生理机制。 在本计划的背景下，这些 研究将与区域大脑的研究相结合 新陈代谢、定量 MRI 和 EEG 功率谱，并将发挥作用 在使用直接替代标记的相关研究中发挥重要作用 HIV-1 感染对中枢神经系统的间接影响。