Driving protective immune responses by targeting Mycobacterium bovis and Foot-and-Mouth Disease virus antigens to bovine dendritic cell subsets

通过将牛分枝杆菌和口蹄疫病毒抗原靶向牛树突状细胞亚群来驱动保护性免疫反应

基本信息

批准号：
BB/F013590/1
负责人：
Bryan Charleston
金额：
$ 101.95万
依托单位：
The Pirbright Institute
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2009
资助国家：
英国
起止时间：
2009 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FF013590%2F1
关键词：
Driving protective immune responses targeting

项目摘要

These studies will help design new vaccines for two important diseases of cattle, bovine tuberculosis and Foot-and-Mouth disease virus. Mycobacterium bovis is the causative agent of bovine tuberculosis (TB), a disease increasing in incidence in UK cattle herds causing major economic losses and potential human health risks. At present control of bovine TB relies solely on the use of diagnostic tests which do not have 100% sensitivity or specificity. Foot and mouth disease virus (FMDV) has a wide host range including all cloven-hoofed animals and causes an acute vesicular disease in domestic ruminants and pigs, which results in debilitation, pain and loss of productivity. Vaccines have been shown to be highly valuable in controlling a variety of infectious diseases, including bacteria and viruses. However, effective vaccines require portions of the infectious agent to be delivered to specialised cells, called dendritic cells. Dendritic cells are the only cells in the body capable of starting an immune response to an agent the body hasn't seen before. Targeting portions of the infectious agents to dendritic cells has been shown to stimulate a strong immune response. Unfortunately, the situation is more complicated than it first appears, there is more than one type of dendritic cell and each cell type can stimulate a different type of immune response. Specific immune responses may be required to control different infections. Acute viral infections, for example Foot-and-Mouth disease, may require an antibody response to control infection. In contrast, slow growing bacterial infections, for example tuberculosis may require immune T cells to control them. In this programme of work we plan to target components of Foot-and-Mouth disease virus or cattle tuberculosis bacteria to particular dendritic cell subsets to determine whther a protective immune response can be stimulated

这些研究将有助于设计新的疫苗，以针对两种重要的牛，牛结核病和口腔疾病病毒设计新疫苗。牛分枝杆菌是牛结核病（TB）的病因，这是英国牛群发病率增加的疾病，导致重大经济损失和潜在的人类健康风险。目前，牛结核病的控制仅依赖于没有100％灵敏度或特异性的诊断测试的使用。脚和口腔疾病病毒（FMDV）的宿主范围很广，包括所有凝结的动物，并在家庭反刍动物和猪中引起急性囊泡疾病，从而导致衰弱，疼痛和生产力丧失。疫苗已被证明在控制各种传染病（包括细菌和病毒）方面具有很高的价值。但是，有效的疫苗要求将一部分传染剂传递到专门的细胞，称为树突状细胞。树突状细胞是人体中唯一能够对人体从未见过的药物进行免疫反应的细胞。已证明将传染剂的部分靶向树突状细胞可刺激强烈的免疫反应。不幸的是，情况比最初出现的情况更为复杂，有多种类型的树突细胞，每种细胞类型都可以刺激不同类型的免疫反应。可能需要特定的免疫反应来控制不同的感染。急性病毒感染，例如脚和口疾病，可能需要对控制感染产生抗体反应。相反，生长缓慢的细菌感染，例如结核病可能需要免疫T细胞来控制它们。在这项工作计划中，我们计划针对脚和口腔疾病病毒或牛结核病细菌的成分，以确定可以刺激保护性免疫反应的特定树突状细胞亚群