UK Veterinary Vaccinology Network

据估计，英国畜牧业包括牛、猪、羊和家禽的年产值约为100亿GB；仅家禽就有40亿GB(全球850亿GB)。养殖鱼的价值每年超过10亿英磅。通过接种疫苗在全球根除牛瘟可能每年为非洲经济节省约10亿英镑。据估计，2007年控制蓝舌病的疫苗的快速部署仅在2008年就为英国经济节省了约5亿GB。通过开发针对广泛传播的传染病的新疫苗，英国畜牧业有巨大的潜力来改善动物福利和经济表现。地方性和外来疾病是新的控制方法的重要目标。例如，牛分枝杆菌是畜牧业目前难以解决的问题，也是疫苗开发的主要挑战。口蹄疫病毒是对英国家畜的持续威胁，目前疫苗的缺陷限制了它们在地方性感染国家和英国暴发期间的有效性。在开发针对各种病原体的疫苗方面存在一些反复出现的挑战，例如，识别保护性抗原，特别是针对大型复杂病原体的保护性抗原，定义保护相关性，了解最有效的抗原传递方法以及与此相关的刺激长期保护性免疫反应。网络将汇集具有广泛技能和经验的科学家来建立团队来解决这些难题。兽医疫苗网络将提供机会，应用基础科学的最新发展来加强对兽医疾病的控制，例如，保护性免疫反应的转录分析，识别T细胞和B细胞表位的高通量方法和抗原传递平台。

The UK livestock industry including cows, pigs, sheep and poultry is estimated to have an annual value of ~£10bn; poultry alone is £4bn (£85bn globally). The value of farmed fish is in excess of £1bn per annum. Global eradication of rinderpest using vaccination probably saves the economies of Africa ~£1bn per annum. The rapid deployment of vaccines to control bluetongue in 2007 is estimated to have saved the UK economy ~£0.5bn in 2008 alone.There is huge potential to improve animal welfare and economic performance of the UK livestock industries by developing new vaccines for widespread infectious diseases. Endemic and exotic diseases are important targets for new control methods. For example, Mycobacterium bovis represents a currently intractable problem for the livestock industry and a major challenge for vaccine development. Foot-and-mouth disease virus is a constant threat to UK livestock and the shortcomings of the current vaccines limit their usefulness in endemically infected countries and during an outbreak in the UK.There are some recurrent challenges in developing vaccines for a wide range of pathogens, for example, identifying protective antigens especially for large complex pathogens, defining correlates of protection, understanding the most effective antigen delivery methods and related to this stimulating long term protective immune responses.The network will bring together scientists with a broad range of skills and experience to build teams to tackle these difficult problems.A veterinary vaccinology network will provide opportunities to apply the latest developments in basic science to enhance control of veterinary diseases, for example, transcriptomic analysis of protective immune responses, high throughput methods to identify T cell and B cell epitopes and antigen delivery platforms.