UK Veterinary Vaccinology Network

据估计，英国畜牧业包括牛、猪、羊和家禽的年价值约为100亿英镑；仅家禽一项就价值40亿英镑（全球价值850亿英镑）。养殖鱼类的价值每年超过10亿英镑。使用疫苗在全球根除牛瘟可能每年为非洲经济节省约10亿英镑。据估计，2007年控制蓝舌病的疫苗迅速投入使用，仅在2008年就为英国经济节省了5亿英镑。通过开发针对广泛传播的传染病的新疫苗，有巨大的潜力来改善动物福利和英国畜牧业的经济表现。地方病和外来病是新的控制方法的重要目标。例如，牛分枝杆菌是畜牧业目前面临的一个棘手问题，也是疫苗开发的一个重大挑战。口蹄疫病毒是对英国牲畜的持续威胁，目前疫苗的缺陷限制了它们在地方性感染国家和在英国爆发期间的有效性。在开发针对多种病原体的疫苗方面，存在一些反复出现的挑战，例如，确定保护性抗原，特别是针对大型复杂病原体的保护性抗原，确定保护的相关因素，了解最有效的抗原递送方法以及与此相关的刺激长期保护性免疫反应。该网络将把具有广泛技能和经验的科学家聚集在一起，建立团队来解决这些难题。兽医疫苗学网络将为应用基础科学的最新发展提供机会，以加强对兽医疾病的控制，例如，保护性免疫反应的转录组学分析，鉴定T细胞和B细胞表位的高通量方法以及抗原递送平台。

The UK livestock industry including cows, pigs, sheep and poultry is estimated to have an annual value of ~£10bn; poultry alone is £4bn (£85bn globally). The value of farmed fish is in excess of £1bn per annum. Global eradication of rinderpest using vaccination probably saves the economies of Africa ~£1bn per annum. The rapid deployment of vaccines to control bluetongue in 2007 is estimated to have saved the UK economy ~£0.5bn in 2008 alone.There is huge potential to improve animal welfare and economic performance of the UK livestock industries by developing new vaccines for widespread infectious diseases. Endemic and exotic diseases are important targets for new control methods. For example, Mycobacterium bovis represents a currently intractable problem for the livestock industry and a major challenge for vaccine development. Foot-and-mouth disease virus is a constant threat to UK livestock and the shortcomings of the current vaccines limit their usefulness in endemically infected countries and during an outbreak in the UK.There are some recurrent challenges in developing vaccines for a wide range of pathogens, for example, identifying protective antigens especially for large complex pathogens, defining correlates of protection, understanding the most effective antigen delivery methods and related to this stimulating long term protective immune responses.The network will bring together scientists with a broad range of skills and experience to build teams to tackle these difficult problems.A veterinary vaccinology network will provide opportunities to apply the latest developments in basic science to enhance control of veterinary diseases, for example, transcriptomic analysis of protective immune responses, high throughput methods to identify T cell and B cell epitopes and antigen delivery platforms.