REPRODUCTIVE BIOLOGY IN PRIMATES: CENTER FACILITIES

这是一个人口中心补助金的竞争性续期申请 (P30)俄勒冈州区域灵长类动物研究中心（ORPRC） 要求支持核心服务，以促进个人研究 具有合格的NICHD使命目标的计划。核心支持是 要求进行放射免疫测定和生物测定（RIA）、形态学（莫尔） 包括电子显微镜和原位杂交，细胞培养 (CC)试剂，未受精和受精配子（IVF-EE），包括 转基因动物，以及用于程序施用（ADM）。研究 小组至少由21名研究者（PI）组成，并有适当的资金 他们利用多学科方法研究灵长类动物 生殖 活跃研究的具体领域包括：神经内分泌事件 影响垂体-性腺轴在青春期前后和 成年人;大脑和生殖道中的类固醇激素机制; 月经周期和妊娠的内分泌生理学; 精子活力;体内和体外受精;基因组过程 阿片肽表达和肾上腺素能受体功能; 生殖光周期性;神经和 生殖组织;以及衰老过程中的神经和内分泌变化。 这些设施的存在将加强 这些单位的成员，并防止不必要的重复设备， 人员和技术。

This is a competitive renewal application for a Population Center Grant (P30) from the OREGON REGIONAL PRIMATE RESEARCH CENTER (ORPRC) that requests support for core services to facilitate individual research programs with qualified NICHD mission objectives. Core support is requested for radioimmunoassays and bioassays (RIA), morphology (MOR) including electron microscopy and in situ hybridization, cell culture (CC) reagents, unfertilized and fertilized gametes (IVF-EE) including transgenic animals, and for program administration (ADM). The research group comprises at least 21 investigators (PIs) with appropriate funding who utilize multidisciplinary approaches for the study of primate reproduction. Specific areas of active research include: neuroendocrine events influencing the hypophyseal-gonadal axis during peripuberty and in adults; steroid hormone mechanisms in the brain and reproductive tract; endocrine physiology of the menstrual cycle and pregnancy; control of sperm motility; in vivo and in vitro fertilization; genomic processes in opiate peptide expression and in adrenergic receptor function; reproductive photoperiodicity; paracrine factors in neural and reproductive tissues; and neural- ana endocrine changes during aging. The existence of these facilities will enhance collaboration among members of these units and prevent unnecessary duplication of equipment, personnel and technologies.