ALZHEIMER DISEASE RESEARCH CENTER

我们建议建立一个阿尔茨海默病研究中心(ADRC)， 将设在杜克大学老龄化研究中心 人类发展。该ADRC项目包括三个模块：1)研究 支持和管理模块，2)脑库和尸检模块，3) 神经放射学模块。这些模块中的每一个都将得到密切协调 有四个初步研究项目和三个试点研究。另外两个 ADRC的组成部分是研究培训方案和社区 教育项目，将扩大他们目前的教学活动 与老龄化中心内的阿尔茨海默氏症(AD)相关。 研究支助单元将延长其正在进行的招聘 适当的患者，继续开展跟踪观察和 数据库程序。它还将负责扩大 家族性阿尔茨海默病与唐氏综合征及其配合的现场研究 为获得常规和快速尸检而作出的安排。这个 脑库和尸检模块将在 AD、DS和对照组脑组织的诊断和处理 并将发展一种快速尸检能力以便新鲜的脑组织 将可用于专门的研究，如 研究项目。神经放射学模块将进行各种 阿尔茨海默病和血管性痴呆患者的影像研究 并将数据与其他两个模块相关联。

We propose to establish an Alzheimer Disease Research Center (ADRC) which will be located in the Duke University Center for the Study of Aging and Human Development. This ADRC project includes three modules: 1) Research Support and Administrative Module, 2) Brain Bank and Autopsy Module, and 3) Neuroradiology Module. Each of these modules will be closely coordinated with four primary research projects and three pilot studies. Two other components in the ADRC are the Research Training Program and the Community Education Project which will expand their current teaching activities related to Alzheimer's disease (AD) within the Aging Center. The Research Support Module will extend its ongoing recruitment of appropriate patients and continue to carry out follow-up observations and data bank procedures. It will also have responsibility for broadening the field studies of familial AD and Down's Syndrome (DS) and coordinate arrangements for obtaining routine and rapid autopsy examinations. The Brain Bank and Autopsy Module will have a major responsibility in diagnosing and processing brain tissues from AD, DS and control subjects and will develop a rapid autopsy capability so that fresh brain tissues will be available for specialized research studies as described in the research projects. The Neuroradiology Module will carry out various imaging studies of patients with Alzheimer's disease and vascular dementia and correlate the data with the other two modules.