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Histone variant macroH2A1 as a novel regulator of memory deficits in Alzheimer's disease

Histone variant macroH2A1 as a novel regulator of memory deficits in Alzheimer's disease
组蛋白变体 MacroH2A1 作为阿尔茨海默病记忆缺陷的新型调节剂
批准号：
478226
负责人：
Zovkic Iva
金额：
$82.2万
依托单位：
University of Toronto Mississauga (ON)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2023
资助国家：
加拿大
项目状态：
未结题
起止时间：
2023-03-01 至 2028-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=478226&lang=en
关键词：
Alzheimer'S Disease Behaviour Brain Epigenetics Gene Expression Histone Variants Macroh2a Memory Mice Neuroscience

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英文摘要
Alzheimer's disease (AD) is a neurodegenerative condition characterized by progressive memory decline that is propagated by impaired regulation of gene expression. We recently identified histone variants as novel regulators of neuronal gene expression and
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Isoform-specific roles of the histone variant macroH2A1 in memory and Alzheimer's disease
Canada Research Chair - Tier 2
  • 批准号：
    415406
  • 项目类别：
  • 资助金额：
    $43.71万
  • 财政年份：
    2019
  • 负责人：
    Zovkic Iva
  • 依托单位：
    University of Toronto
Histone variant H2A.Z as a novel therapeutic target for Alzheimer's disease
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