ALZHEIMERS DISEASE RESEARCH CENTER

这是约瑟夫和凯瑟琳布赖恩阿尔茨海默氏症的第二次更新 疾病研究中心（布赖恩ADRC），在杜克大学医学中心， 北卡罗来纳州达勒姆：艾伦D。玫瑰医学博士，主要研究者兼主任， Donald E. Schmechel，医学博士和凯瑟琳A.威尔士语博士副 董事们。布赖恩ADRC的总体具体目标是：（l）提供 诊断、预防和治疗痴呆症的专业知识 疾病;（2）提供确定的结构和背景。 评估、纵向跟踪和研究参与 （3）传播“独特的” 组织并为内部和外部研究提供所需的资源; (4)提供一个积极的临床中心， 临床研究;和，（5）进行研究，导致进步， AD生物学该中心的结构由五个互动的 核心：核心A -管理核心：核心B -临床研究 开发核心，核心C -神经病理学核心，包括快速尸检 协议（RAP）和控制尸检子单元与迈阿密大学： 核心D -教育和信息研究培训核心和核心E - 信息学核心。布赖恩ADRC已经建立了一个宝贵的资源， 脑组织此外，该中心在以下方面的成就 分子遗传学研究，特别是APOE 4作为一种 AD的主要遗传易感基因，现在已经很好地确定。到 为了进一步阐明APOE 4的作用，本申请包括五项研究 项目：项目1 -“ApoE在体外的异构体特异性相互作用。“W. Strittmatter，PI;项目2 -“ApoE与神经元 AD中的漏洞。“D. Schmechel，PI;项目3 -“亚细胞 载脂蛋白E异构体的运输，”A.桑德斯，PI;项目4 -“蜂窝 ApoE 3和ApoE 4的加工，”M. Sheetz、PI和项目5 -“生产 和ApoE转基因小鼠的分析。“J.吉尔伯特，PI。两个试点项目 包括：试点项目1 -“神经心理-神经病理 AD的相关性，“M。Murray，PI和试点项目2 -“老年痴呆症研究 卡托巴族SC“F.艾伦，PI。布莱恩ADRC成功地 整合、协调和培养的跟踪记录 成熟的和发展中的调查人员的跨学科合作。 Bryan ADRC提供了重要的 资源的地方，国家和国际环境。这些 中心资源将不断加强独立性和协作性 研究工作，提高生产力，并产生新的想法，所有的目的 在进一步确定AD和其他痴呆的原因时， 疾病和发展预防、护理和治疗 为疾病受害者及其家人制定的战略。

This is the second renewal of the Joseph and Kathleen Bryan Alzheimer's Disease Research Center (Bryan ADRC), at Duke University Medical Center, Durham, NC: Allen D. Roses. M.D., Principal Investigator and Director, Donald E. Schmechel, M.D. and Kathleen A. Welsh. Ph.D.. Associate Directors. The overall specific aims of the Bryan ADRC are to: (l) provide expertise for the diagnosis, prevention, and treatment of dementing illnesses; (2) provide the structure and context for the ascertainment. evaluation, longitudinal follow-up and research participation of large families of AIzheimer's disease (AD) patients; (3) disseminate "unique" tissue and provide needed resources for internal and external research; (4) provide an active clinical center for participation in therapeutic clinical research; and, (5) perform research leading to advances in the biology of AD. The Center's Structure is composed of five interactive Cores: Core A - Administrative Core: Core B - Clinical Research Development Core, Core C - Neuropathology Core including the Rapid Autopsy Protocol (RAP) and a Control Autopsy subunit with the University of Miami: Core D - Education and Information Research Training Core: and Core E - Informatics Core. The Bryan ADRC has built a valuable resource of fresh brain tissue through the RAP. In addition, the Center's accomplishments in molecular genetic studies, specifically the identification of APOE4 as a major genetic susceptibility gene for AD, are now well established. To further clarify the role of APOE4, this application includes five research projects: Project 1 - "Isoform-specific Interactions of ApoE in vitro." W. Strittmatter, PI; Project 2 - "Relationship of ApoE to Neuronal Vulnerability in AD." D. Schmechel, PI; Project 3 - "Subcellular Trafficking of ApoE Isoforms," A. Saunders, PI; Project 4 - "Cellular Processing of ApoE3 and ApoE4," M. Sheetz, PI, and Project 5 - "Production and Analysis of ApoE Transgenic Mice. " J. Gilbert, PI. Two pilot projects are included: Pilot Project 1 - "Neuropsychological-Neuropathological Correlates of AD," M. Murray, PI and Pilot Project 2 - "Dementia Study of the SC Catawba Nation. " F. Allen, PI. The Bryan ADRC has a successful track record for integrating, coordinating, and fostering interdisciplinary cooperation of established and developing investigators. The Bryan ADRC provides for the continued availability of important resources to the local, national, and international environment. These Center resources will continue to strengthen independent and collaborative research efforts, increase productivity, and generate new ideas all aimed at further identification of the cause(s) of AD and other dementing illnesses and the development of prevention, care, and treatment strategies for disease victims and their families.