CLINICAL RESEARCH CENTER FOR OPIOID AND COCAINE ABUSE

阿片类药物和可卡因滥用临床研究中心 有组织地发展新的认识和治疗 对这样的虐待者。 为了实现这一目标，我们将 一系列针对人类的研究项目， 为新的研究人员提供培训和研究机会 与一系列专业学科，并促进交流 来自耶鲁大学医学院不同部门的研究人员 中心，因为他们专注于可卡因和阿片类药物滥用问题。 该中心将由核心设施相连的三个部门组成 和工作人员： a. 治疗研究司-开发和测试 可卡因和类阿片滥用的创新治疗方法，B. 神经生物学部-神经生物学相关研究 人类阿片类药物和可卡因的使用和戒断，c. 流行病学司-确定具有临床意义的 阿片类药物和可卡因滥用人群中的亚组。 核心工作人员将负责：质量监控 并指导内部不同研究工作的方向， 中心，并提供咨询和援助， 开展中心的重大研究项目，B。协调 通过监督受训人员、提供研究 研讨会，并提供技术和物质援助， 学员的研究项目，以及c.鼓励和支持 由两名受训人员开展试点和/或小型研究项目 和教职员工。 在这个应用程序中，我们描述了前四个主要的 通过中心进行的调查包括：1。 这是第一项针对人类的全面研究， 阿片类药物滥用者从激动剂到激动剂/拮抗剂到拮抗剂 这将提高我们让病人摆脱美沙酮的能力 维护和拮抗剂。 2.对急性 可卡因对接受可卡因治疗的患者的影响 纳洛酮，美沙酮，或三环类抗抑郁药， 对这些药物的使用提出新的观点，3。一个 戒断时受体和神经生物学变化的评价 从阿片类药物，可以提供一个更全面的 了解退出过程; 4.的研究 父母教养质量与儿童精神病理的关系 阿片类药物成瘾，这可能导致制定战略， 来预防阿片类药物成瘾儿童的发病率。

A Center for Clinical Research on Opioid and Cocaine Abuse will be organized to develop new understanding of and treatment approaches to such abusers. To achieve this goal, we will conduct a programmatic series of research investigations in humans, provide training and research opportunities for new investigators with a range of professional disciplines, and stimulate interchange among investigators from different sections of the Yale Medical Center as they focus on problems of cocaine and opioid abuse. The Center will consist of three Divisions linked by Core facilities and staff: a. Treatment Research Division--development and testing of innovative treatment approaches for cocaine and opioid abuse, b. Neurobiology Division--investigation of neurobiological correlates of opioid and cocaine use and withdrawal in humans, c. Epidemiology Division--identification of clinically significant subgroups within the population of opioid and cocaine abusers. The Core staff will be charged with: a. Monitoring the quality and guiding the direction of disparate research endeavors within the Center as well as providing consultation and assistance in the conduct of the Center's major research projects, b. Coordinating training efforts by supervising trainees, providing research seminars, and providing technical and material assistance in trainee's research projects, and c. stimulating and supporting the conduct of pilot and/or small research projects by both trainees and faculty members. With this application we describe the first four major investigations to be undertaken through the Center including: 1. the first comprehensive study in humans to assess the transition of opioid abusers from agonist to agonist/antagonist to antagonist which would improve our ability to get patients off methadone maintenance and onto antagonist. 2. an evaluation of the acute effects of cocaine on patients undergoing treatment with Naltrexone, Methadone, or tricyclic antidepressants, which could suggest new perspectives on the use of these agents, 3. an evaluation of receptor and neurobiological changes in withdrawal from opioids which could provide a more comprehensive understanding of the withdrawal process, and 4. a study of the relationship between quality of parenting and psychopathology in opioid addicts which could lead to the development of strategies to prevent morbidity in opioid addicts' children.