CLINICAL RESEARCH CENTER FOR OPIOID AND COCAINE ABUSE

阿片类药物和可卡因滥用临床研究中心将成立 有组织地发展新的认识和治疗 针对这类施虐者的方法。为了实现这一目标，我们将进行 在人类身上进行的一系列程序性研究调查， 为新的调查人员提供培训和研究机会 与一系列专业学科相结合，并刺激交流 来自耶鲁大学医学院不同部门的调查人员 他们把重点放在可卡因和阿片类药物滥用问题上。 该中心将由三个部门组成，由核心设施连接起来 和员工： A.治疗研究司--开发和测试 针对可卡因和阿片类药物滥用的创新治疗方法，b. 神经生物学分部--神经生物学相关研究 阿片类药物和可卡因在人类中的使用和戒断，c. 流行病学部--临床上有意义的鉴定 阿片类药物和可卡因滥用人群中的亚群。 核心员工将负责：a.监督质量 并为内部不同的研究努力指明方向 该中心还提供咨询和援助， 开展中心的主要研究项目，b.协调 通过监督受训者、提供研究来进行培训 研讨会，并在以下方面提供技术和物质援助 学员的研究项目，以及C.激励和支持 由两名受训人员进行试点和/或小型研究项目 和教职员工。 通过这个应用程序，我们描述了前四个主要的 将通过该中心进行的调查包括：1. 首次在人类身上进行全面研究来评估这一转变 阿片类药物滥用者从激动剂到激动剂/拮抗剂到拮抗剂 这将提高我们让患者停用美沙酮的能力 维护和升级为敌手。2.对急症患者的评估 可卡因对慢性阻塞性肺疾病治疗患者的影响 纳曲酮、美沙酮或三环类抗抑郁药，这些药物可能 对这些药物的使用提出新的观点，3.和 戒断时受体和神经生物学变化的评价 从阿片类药物中可以提供更全面的 对撤军过程的理解；4.对撤军进程的研究 父母教养质量与心理病理的关系 可能导致制定策略的阿片成瘾者 以防止阿片类药物成瘾者子女的发病率。

A Center for Clinical Research on Opioid and Cocaine Abuse will be organized to develop new understanding of and treatment approaches to such abusers. To achieve this goal, we will conduct a programmatic series of research investigations in humans, provide training and research opportunities for new investigators with a range of professional disciplines, and stimulate interchange among investigators from different sections of the Yale Medical Center as they focus on problems of cocaine and opioid abuse. The Center will consist of three Divisions linked by Core facilities and staff: a. Treatment Research Division--development and testing of innovative treatment approaches for cocaine and opioid abuse, b. Neurobiology Division--investigation of neurobiological correlates of opioid and cocaine use and withdrawal in humans, c. Epidemiology Division--identification of clinically significant subgroups within the population of opioid and cocaine abusers. The Core staff will be charged with: a. Monitoring the quality and guiding the direction of disparate research endeavors within the Center as well as providing consultation and assistance in the conduct of the Center's major research projects, b. Coordinating training efforts by supervising trainees, providing research seminars, and providing technical and material assistance in trainee's research projects, and c. stimulating and supporting the conduct of pilot and/or small research projects by both trainees and faculty members. With this application we describe the first four major investigations to be undertaken through the Center including: 1. the first comprehensive study in humans to assess the transition of opioid abusers from agonist to agonist/antagonist to antagonist which would improve our ability to get patients off methadone maintenance and onto antagonist. 2. an evaluation of the acute effects of cocaine on patients undergoing treatment with Naltrexone, Methadone, or tricyclic antidepressants, which could suggest new perspectives on the use of these agents, 3. an evaluation of receptor and neurobiological changes in withdrawal from opioids which could provide a more comprehensive understanding of the withdrawal process, and 4. a study of the relationship between quality of parenting and psychopathology in opioid addicts which could lead to the development of strategies to prevent morbidity in opioid addicts' children.