The effects of acute stress on glutamate receptor trafficking and synaptic plasticity in the hippocampus

动物适应不断变化的环境的能力对其生存至关重要。其中一个非常重要的方面是中枢神经系统对压力的反应能力。在对应激源的最初急性反应期间，动物需要提高警惕，并能够将其注意力、能量和认知功能集中在解释和应对感知到的危险上。在这个急性反应阶段之后，动物需要调整其唤醒状态，并储存适当的事件记忆，以备将来再次发生类似危险时参考。如果动物继续受到重复或长时间的压力-特别是如果它们是不可预测的，动物几乎没有能力控制或避免它们-压力反应变得适应不良，导致认知功能丧失，并与生理和心理障碍有关。在这个应用程序中，我们打算调查在急性应激反应的早期阶段/提高警惕的时候发生的突触功能的变化。

The ability of an animal to adapt to a changing environment is critically important for its survival. A very important aspect of this is the ability of the central nervous system to respond to periods of stress. During the initial acute response to a stressor the animal needs heightened vigilance and the ability to focus its attention, energy and cognitive functions on interpreting and responding to the perceived danger. Following this acute response phase the animal needs to tune down its aroused state and store appropriate memories of the event for future reference should similar dangers recur. If the animal continues to be subjected to repeated or prolonged stresses - particularly if they have been unpredictable and the animal has little or no ability to control or avoid them - the stress responses become maladaptive and result in loss of cognitive function and is associated with both physical and psychological disorders. In this application we intend to investigate the changes in synaptic function that occur during the early phase of the acute stress response / the time of heightened vigilance.