SUPPORT FOR REGIONAL PRIMATE RESEARCH CENTER

该中心的研究计划包含在其所有三个 分裂生殖生物学和行为，最大的部门， 13名科学家，拥有广泛的计划，涉及许多 生殖方面，如控制排卵的机制， 黄体功能：生殖组织对类固醇激素的反应 激素;精子活力和成熟：体外和体内 受精;着床;分娩;基因的激素调节 在卵巢、睾丸和子宫中表达;细胞间通讯： 控制催乳素分泌和生殖行为。 神经科学部的六位科学家的研究重点是 控制青春期发育的细胞和分子机制 调节基因表达、神经元的分化和生长， 脑生长因子对少突胶质细胞增殖和 调节、免疫系统对髓鞘形成的影响以及免疫调节剂的用途。 多克隆和单克隆抗体，以研究下丘脑发育。 目前有四个灵长类动物医学研究项目，这些 重点研究黑猕猴自发性糖尿病，饮食因素 影响动脉粥样硬化的预防和消退， 免疫反应与猴获得性免疫缺陷病毒的生物学和病理学 免疫缺陷病（SAIDS）。两个人正在进行中 病毒学家，预计这些科学家将参与 与SAIDS有关的项目。 除上述外，中心工作人员继续设法 改善动物护理，与其他机构的互动， 增加资源以支持研究。

The center's research programs are contained in all three of its divisions. Reproductive Biology and Behavior, the largest division with 13 scientists, houses a broad spectrum of programs that involve many facets of reproduction, such as mechanisms that control ovulation and corpora lutea functions: responses of reproductive tissues to steroid hormones; sperm motility and maturation: in vitro and in vivo fertilization: implantation: parturition; hormonal regulation of gene expression in ovary, testes, and uterus; cell-to-cell communication: control of prolactin secretion and reproductive behavior. Research by the six scientists in the Division of Neuroscience focuses on the cell and molecular mechanisms that control puberty, developmental regulation of gene expression, differentiation and growth of neurons, effects of brain growth factors on oligodendrocyte proliferation and modulation, effects of the immune system on myelination and use of polyclonal and monoclonal antibodies to study hypothalamic development. There are presently four research programs in Primate Medicine, and these focus on spontaneous diabetes mellitus in Macaca nigra, dietary factors that affect prevention and regression of atherosclerosis, mechanisms of immune responses and the biology and pathology of simian acquired immunodeficiency disease (SAIDS). Searches are underway for two virologists, and it is expected that these scientists will be involved in SAIDS-related projects. In addition to the above, the Center's staff continues to seek ways to improve animal care, interactions with other institutions and ways to enhance resources for the support of research.