SUPPORT FOR REGIONAL PRIMATE RESEARCH CENTER

支持区域灵长类研究中心

• 批准号: 3107906
• 负责人: PETER Ogden KOHLER
• 金额: $ 562.71万
• 依托单位: OREGON REGIONAL PRIMATE RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-05-01 至 1994-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3107906
• 关键词: Primates; animal colony

The center's research programs are contained in all three of its divisions. Reproductive Biology and Behavior, the largest division with 13 scientists, houses a broad spectrum of programs that involve many facets of reproduction, such as mechanisms that control ovulation and corpora lutea functions: responses of reproductive tissues to steroid hormones; sperm motility and maturation: in vitro and in vivo fertilization: implantation: parturition; hormonal regulation of gene expression in ovary, testes, and uterus; cell-to-cell communication: control of prolactin secretion and reproductive behavior. Research by the six scientists in the Division of Neuroscience focuses on the cell and molecular mechanisms that control puberty, developmental regulation of gene expression, differentiation and growth of neurons, effects of brain growth factors on oligodendrocyte proliferation and modulation, effects of the immune system on myelination and use of polyclonal and monoclonal antibodies to study hypothalamic development. There are presently four research programs in Primate Medicine, and these focus on spontaneous diabetes mellitus in Macaca nigra, dietary factors that affect prevention and regression of atherosclerosis, mechanisms of immune responses and the biology and pathology of simian acquired immunodeficiency disease (SAIDS). Searches are underway for two virologists, and it is expected that these scientists will be involved in SAIDS-related projects. In addition to the above, the Center's staff continues to seek ways to improve animal care, interactions with other institutions and ways to enhance resources for the support of research.

该中心的研究计划包含在其所有三个 组织。生殖生物学和行为，最大的部门，有 13名科学家，拥有广泛的项目，涉及许多 生殖的各个方面，如控制排卵和 黄体功能：生殖组织对类固醇的反应 激素；精子活力和成熟：体外和体内 受精：植入：分娩；基因的激素调节 在卵巢、睾丸和子宫中的表达；细胞间的通讯： 控制催乳素分泌和生殖行为。 神经科学部的六位科学家的研究重点是 控制青春期、发育的细胞和分子机制 基因表达、神经元分化和生长的调控， 脑生长因子对少突胶质细胞增殖和分化的影响 调节，免疫系统对髓鞘形成的影响和使用 多克隆和单抗用于研究下丘脑发育。 目前有四个灵长类医学研究项目，这些 关注猕猴自发性糖尿病的饮食因素 影响动脉粥样硬化的预防和消退，其机制 获得性免疫反应与猿猴的生物学和病理学 免疫缺陷疾病(SAID)。目前正在搜寻其中两人 病毒学家，预计这些科学家将参与到 SADS相关项目。 除上述外，该中心的工作人员继续想方设法 改善动物护理、与其他机构的互动以及 增加支持研究的资源。