CBF AND METABOLISM IN STROKE AND SHOCK

该计划的总体目标是确定有助于 各种形式的缺氧或缺血引起的不可逆脑损伤 并将这些信息应用于临床情况。 此外，更好的 了解正常情况下脑血流动力学的控制， 被人追杀 目前正在采用各种办法解决这些问题。 上 在基础水平上，正在研究中风和休克的动物模型。 区域 脑血流量和局部脑葡萄糖代谢以及 线粒体功能，离子通量，组织代谢物，皮质氧化还原状态， 和超微结构的变化。 此外，发展 目前正在采用适用于这些问题的新方法。 临床 水平，脑血管疾病患者正在进行研究，试图 改善预后。 重症监护和监测患者 急性中风正在进行，以确定这种方法是否可以 有利地改变这些案件的结果。 轻度升高的影响 中风急性期的血压将在一个双 随机盲法研究。 此外，还提供了关于 rCBF测量和认知功能研究在患者评估中的应用 急性中风和短暂性脑缺血发作 类似的研究将 在接受颈动脉内膜切除术和显微外科手术的患者中进行 吻合术 在后一组中，皮质氧化还原状态也将被评估。 术中。

The overall goals of the program are to determine the factors contributing to the irreversible cerebral damage caused by various forms of hypoxia or ischemia and to apply this information to the clinical situation. In addition, a better understanding of the control of cerebral hemodynamics in the normal situation is being pursued. Various approaches to these problems are being utilized. On a basic level, animal models of stroke and shock are being studied. Regional cerebral blood flow and regional cerebral glucose metabolism as well as mitochondrial function, ion fluxes, tissue metabolites, cortical redox state, and ultrastuctural changes are being examined. In addition, the development of new methodology applicable to these problems is being pursued. On the clinical level, patients with cerebrovascular disease are being studied in an attempt to improve their prognosis. The intensive care and monitoring of patients with acute strokes is being undertaken to determine whether such as approach can favorably alter the outcome in these cases. The effect of mild elevation of blood pressure during the acute phase of stroke will be evaluated in a double blind randomized study. In addition, information concerning the usefulness of rCBF measurements and cognitive function studies in the evaluation of patients with acute strokes and T,I.A,'s will be obtained. Similar studies will be performed in patients undergoing carotid endarterectomy and microsurgical anastomosis. In the latter group cortical redox state will also be evaulated intraoperatively.