LOCAL CEREBRAL GLUCOSE METABOLISM

PET研究计划包括三个项目和相关的 进行这些研究所需的核心设施。 这些项目代表了 我们在精神分裂症、癫痫和 帕金森氏症。 这些项目的共同点是 研究大脑对激活任务的反应变化。 这不仅将提供有关潜在的重要信息， 在疾病状态下，这些过程在大脑中的重组，但 帮助我们理解组织和处理这些 正常大脑中的信息。 在项目10中，PET激活研究将用于检查大脑 功能和精神分裂症的神经基板的搜索。 这项研究是 旨在评估大脑异常的区域特异性 对认知挑战任务的激活反应。 此外，模式 静息糖代谢的变化与病程有关。 项目11将研究人类脑损伤和功能恢复， 颞叶癫痫（TLE）。 它将评估认知组织， 包括语言和记忆，由于最初的伤害造成的， 癫痫 该项目将评估认知重组 前颞叶切除术（ATL）后，以确定哪些区域的 大脑参与恢复，并检查术前组织， 根据第一次脑损伤时的年龄，在ATL后进行重组。 项目12将解决围绕存在和性质的争议 帕金森病患者的认知和语言缺陷 （PD）。 拟议的研究将描述 这些患者的认知缺陷，并将认知表现与 正电子发射断层扫描（PET）的脑功能。

This program of PET research contains three projects and the associated core facilities necessary to conduct these studies. The projects represent a continuation of our studies in patients with schizophrenia, epilepsy and Parkinson's disease. A common thread among these projects will be the study of the alterations in the cerebral response to activation tasks. This will not only provide important information concerning the potential reorganization of these processes in the brain in disease states, but will aid in our understanding of the organization and processing of such information in the normal brain. In Project 10, PET activation studies will be used to examine brain function and search for neural substrates of schizophrenia. The study is designed to evaluate the regional specificity of abnormalities in brain activation response to cognitive challenge tasks. In addition, the pattern of resting glucose metabolism will be related to the course of illness. Project 11 will study brain injury and recovery of function in humans with temporal lobe epilepsy (TLE). It will assess cognitive organization, including language and memory, consequent to the initial injury causing the epilepsy. The project will then evaluate cognitive reorganization following anterior temporal lobectomy (ATL) to determine which areas of the brain participate in recovery, and examine pre-operative organization and reorganization after ATL in light of age at the time of first brain injury. Project 12 will address the controversy surrounding the presence and nature of cognitive and language deficits in patients with Parkinson's disease (PD). The proposed study will characterize the prevalence and nature of cognitive deficits in these patients, and relate cognitive performance to cerebral function with positron emission tomography (PET).