CBF & METABOLISM IN AGING AND DEMENTIA

痴呆症是老年人残疾的主要原因，有 65岁以上人群的患病率为15%。这项研究是设计的 研究与脑部结构和功能相关的改变 正常衰老和痴呆症。了解这些机制将会有所帮助。 在制定预防、诊断和治疗认知障碍的策略时 老龄化人口的恶化。 近期目标是：(1)评估全球和区域变化 老年性痴呆患者脑血流量的变化 儿童脑血流量异常与心理障碍的关系 痴呆；(3)用特定的认知评估刺激的效果 正常衰老和痴呆患者的脑血流量任务；(4)研究两者之间的关系 老年人脑萎缩与脑血流量减少之间的关系； 描述不同年龄组和地区的31P-核磁共振波谱模式 痴呆症亚型(阿尔茨海默氏型、多发性梗死型和帕金森病)。 局部脑血流量将使用静脉血流量测量 氙气-133注入技术，其优点是 非侵入性、既定的和可重复的量化方法， 适用于老年人口时的有效性，以及在 激活研究。受试者将被严格评估是否存在 包括无症状颈动脉在内的脑血管危险因素 对疾病进行非侵入性评估，以期分开治疗效果 原发性脑实质变性引起的血管改变是脑血流的一个原因 减少衰老。质子核磁共振成像将作为一种新的、有前途的成像技术 评估脑萎缩和多发梗死灶变化的技术 痴呆症(中)。一项更新的发展，体内31P-核磁共振波谱， 将被用来衡量依赖磷酸盐的地区差异 生物能量学。所有全球和区域的生理和解剖数据 将与一般的和特定的心理缺陷相关 这些主题。 由此获得的信息可能会提高我们对潜在问题的理解 衰老障碍的病理生理过程及未来展望 努力开发有效的治疗方式。

Dementia is a leading cause of disability among the elderly, with a prevalence rate of 15% in individuals over age 65. This study is designed to investigate changes in cerebral structure and function associated with normal aging and dementia. An understanding of these mechanisms will help in developing strategies to prevent, diagnose, and treat cognitive deterioration in the aging population. The immediate objectives are to: (1) evaluate global and regional changes in cerebral blood flow (CBF) in aging and dementia; (2) investigate the relationship between abnormalities in CBF and psychological deficits in dementia; (3) assess the effects of stimulation with specific cognitive tasks on CBF in normal aging and dementia; (4) study the relationship between cerebral atrophy and CBF reductions in the elderly; and (5) describe regional 31P-NMR spectroscopic patterns in various age groups and dementia sub-types (Alzheimer's type, multi-infarct, and Parkinsonian). Regional cerebral blood flow will be measured using the intravenous Xenon-133 injection technique, which has the advantages of non-invasiveness, established and reproducible quantification methods, validity when applied to an aged population, and ease of implementation in activation studies. Subjects will be rigorously evaluated for the presence of cerebrovascular risk factors including asymptomatic carotid artery disease assessed non-invasively, in order to separate the effect of vascular changes from primary parenchymal degeneration as a cause of CBF reduction in aging. Proton-NMR imaging will be used as a new and promising technique for assessing cerebral atrophy and changes of multi-infarct dementia (MID). An even newer development, in vivo 31P-NMR spectroscopy, will be employed to measure regional variations in phosphate-dependent bioenergetics. All global and regional physiological and anatomical data will be correlated with the general and specific psychological deficits in these subjects. The information thus gained may improve our understanding of underlying pathophysiological processes in disorders of aging, and direct future efforts to develop effective therapeutic modalities.