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AMINO ACIDS AND BEHAVIOR IN ALCOHOLISM

氨基酸与酗酒行为

基本信息

批准号：
3109670
负责人：
LAURE B BUYDENS-BRANCHEY
金额：
$ 6.75万
依托单位：
MOUNT SINAI SCHOOL OF MEDICINE OF CUNY
依托单位国家：
美国
项目类别：
财政年份：
1984
资助国家：
美国
起止时间：
1984-08-01 至 1987-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3109670
关键词：
aggression alcoholism /alcohol abuse aminoacid metabolism brain metabolism depression detoxification human middle age (35-64) human subject mental disorder chemotherapy suicide toxin metabolism tryptophan young adult human (21-34)

项目摘要

We intend to do long term assessments of relationships between alcohol consumption, modifications in amino acids which are the precursors of neutrotransmitters, and 3 types of behavior i.e., depression, suicide and aggression in alcoholic patients. We have recently observed that, when compared with non-depressed alcoholics and controls, depressed alcoholics had significantly decreased ratios of plasma tryptophan to amino acids sharing with it the same transport carrier into the brain (tryptophan ratio). This ratio has been shown to predict the brain serotonin concentration. It is not presently known whether amino acid modifications disappear after a period of abstinence or persist. We will conduct studies aimed at elucidating this question. If biochemical changes persisted they could represent anomalies increasing the affected individuals' vulnerability to depression and should alert us to maintain heightened vigilance when treating these patients. We obtained preliminary data showing an association between a low tryptophan ratio depression and suicide attempts. Because associations had been found recently between suicidal and aggressive tendencies and because both types of behavior have been linked to lowered CSF levels of serotonin main metabolite, we studied relationships between amino acid modifications and manifestations of aggression in alcoholics. Patients who had exhibited violent behavior were observed to have tryptophan ratios lower than patients with no history of violence. Our studies need to be expanded and carried out in larger number of patients subjected to more extensive psychiatric assessments and to long term follow-up evaluations. The identification of biological factors contributing to depression or suicidal and aggressive behavior is important because the psychological and social costs of these types of behavior are great. In addition, it would be important to know that certain forms of mental disease would lend themselves to the relatively atraumatic therapy of amino acid supplementation.

我们打算对酒精之间的关系进行长期评估氨基酸的消耗和修饰，这些氨基酸是中性递质和 3 种行为，即抑郁、自杀和酗酒者的攻击行为。我们最近观察到，与非抑郁的酗酒者相比和对照组相比，抑郁的酗酒者的比率显着降低血浆色氨酸至氨基酸与其共享相同的运输载体进入大脑（色氨酸比率）。该比率已被证明可以预测大脑血清素浓度。目前尚不清楚氨基是否禁欲一段时间后，酸修饰会消失或持续存在。我们将进行旨在阐明这个问题的研究。如果生化变化持续存在，它们可能代表异常现象，增加了受影响的影响个人容易患抑郁症，应该提醒我们保持治疗这些患者时要提高警惕。我们获得了初步数据，显示低水平之间存在关联色氨酸比率抑郁和自杀企图。因为协会有最近发现自杀倾向和攻击倾向之间存在，因为这两种行为都与脑脊液血清素水平降低有关主要代谢物，我们研究了氨基酸修饰之间的关系以及酗酒者的攻击性表现。曾出现过表现的患者观察到暴力行为的色氨酸比率低于无暴力史的患者。我们的研究需要扩大和在大量患者中进行，接受更广泛的治疗精神病学评估和长期随访评估。识别导致抑郁症或抑郁症的生物因素自杀和攻击行为很重要，因为心理和攻击行为这类行为的社会成本是巨大的。此外，它还会重要的是要知道某些形式的精神疾病会导致他们自己对相对无创的氨基酸疗法补充。