SEXUAL BEHAVIOR AND HORMONES IN AGING MALES

老年男性的性行为和激素

• 批准号: 3114237
• 负责人: CHARLES H PHOENIX
• 金额: $ 13.79万
• 依托单位: OREGON REGIONAL PRIMATE RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-07-01 至 1987-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3114237
• 关键词: adrenergic agents; aging; animal old age; behavior test; cortisol; dihydrotestosterone; estradiol; ethology; hormone regulation /control mechanism; isolation /deprivation; longitudinal animal study; luteinizing hormone; male; male castration; mature animal; operant conditionings; prolactin; psychophysiology; radioimmunoassay; reproductive hormone; sex behavior; social behavior; sperm motility; testosterone

We propose to extend our research to identify factors other than testosterone (T) that may account for the decline in sexual behavior of aging males. Because the old male primates (24 years and older) that will serve as subjects are nearing maximum life expectancy, and many have been under study for over 15 years, this is a unique research opportunity. Our aims are to determine (1) sexual behavior and serum hormone levels in very old rhesus males and the effects of increasing T levels on sexual behavior, (2) the extent to which failing health in very old males reduces sexual activity and its effect on serum hormone levels, (3) threshold levels of T that will induce levels of sexual behavior in old (24 years and older) long-term-castrated males that are comparable to those of intact males of the same age, (4) the extent to which penile reflexes correlate with sexual performance and serum T levels in old intact and castrated males, (5) whether differences in the sexual behaviors of young (mean of 12 years) and old males observed in laboratory pair tests also occur in a semi-naturalistic social environment, (6) the differences (physiological and behavioral) between the few preferred females who can arouse old rhesus males to copulate and most other females, who cannot, (7) whether sperm motility and fertility, like sexual behavior, decline in old rhesus males whose serum T levels are within the range for young males, (8) whether drugs that act on the dopaminergic and serotoninergic systems influence sexual behavior in old males, (9) whether living in isolation increases the rate of decline in sexual behavior and influences serum testosterone levels in old rats, and (10) whether the deterioration of penile papillae that we have observed in old rats reflects a decrease in tissue sensitivity or reflects a decrease in serum T levels. The research seeks answers to questions relevant to aging male mammals in general, but each experiment is relevant in varying degrees to the problems of sexual behavior confronting old men. The focus is on behavior, but answers must be drawn from a number of disciplines, including endocrinology, anatomy, physiology, and comparative psychology. Our findings should be of interest to practicing sex therapists as well as professors of geriatrics.

我们建议扩大我们的研究范围，以确定除 睾酮（T）可能是导致性行为下降的原因 老年男性。 因为年老的雄性灵长类动物（24岁及以上）会 作为受试者已接近最大预期寿命，并且许多人已经 研究已经超过 15 年，这是一个独特的研究机会。 我们的 目的是确定（1）非常多的人的性行为和血清激素水平 年老的雄性恒河猴以及增加 T 水平对性行为的影响， (2) 高龄男性健康状况不佳会在多大程度上降低性能力 活性及其对血清激素水平的影响，（3）T 的阈值水平 这会诱发老年人（24 岁及以上）的性行为水平 长期阉割的雄性与未绝育的雄性相当 相同年龄，（4）阴茎反射与性行为相关的程度 老年完整和阉割雄性的性能和血清 T 水平，(5) 年轻人（平均12岁）和年轻人的性行为是否存在差异 在实验室配对测试中观察到的老年男性也发生在 半自然社会环境，（6）差异（生理 和行为）在少数能激起老恒河猴偏好的雌性之间 雄性能够与大多数其他雌性交配，但不能，（7）是否有精子 运动能力和生育能力，如性行为，年老雄性恒河猴的衰退 其血清T水平在年轻男性的范围内，（8）是否 作用于多巴胺能和血清素能系统的药物影响 老年男性的性行为，（9）隔离生活是否会增加 性行为下降率并影响血清睾酮水平 在老年大鼠中，以及（10）我们认为阴茎乳头是否退化 在老年大鼠中观察到反映了组织敏感性的下降或 反映了血清T水平的降低。 该研究寻求以下问题的答案 一般来说，问题与衰老的雄性哺乳动物有关，但每个实验都是 与所面临的性行为问题有不同程度的相关性 老人们。 重点是行为，但答案必须从数字中得出 学科，包括内分泌学、解剖学、生理学和 比较心理学。 我们的发现应该对实践感兴趣 性治疗师以及老年病学教授。