SEXUAL BEHAVIOR AND HORMONES IN AGING

性行为与衰老过程中的激素

• 批准号: 3114240
• 负责人: CHARLES H PHOENIX
• 金额: $ 16.94万
• 依托单位: OREGON REGIONAL PRIMATE RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-07-01 至 1991-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3114240
• 关键词: Macaca mulatta; adrenergic agents; aging; animal old age; behavior test; cortisol; dihydrotestosterone; estradiol; ethology; hormone regulation /control mechanism; isolation /deprivation; longitudinal animal study; luteinizing hormone; male; male castration; mature animal; operant conditionings; prolactin; psychobiology; radioimmunoassay; reproductive hormone; sex behavior; social behavior; sperm motility; testosterone

The-long term objectives of this research program are to identify those factors that cause or are associated with the decline in sexual activity that accompanies old age. Our research is focused on the decline in sexual behavior and accompanying changes in the hormonal milieu of aging rhesus macaques for what that research may contribute to an understanding of the decline in sexual behavior of aging primates, including man. In a society whose population is steadily growing older, the need for such research grows in importance. Our research is experimental, interdisciplinary, and includes the quantitative assessment of behavioral endpoints following manipulation of environmental, and hormonal variables. Our specific aims are to determine: (1) the extent to which manipulation of environmental conditions such as the social situation and sexual partner can modify sexual performance in old males and hence permit us to assess the degree to which the decline in sexual performance is dependent upon psychological variables (2) the extent to which the decline in sexual performance is related to the competency of the brain- pituitary-gonadal system in old males as that system governs the hormonal environment modulating sexual performance and reproductive function (3) the specific changes in sexual behavior that occur over time with associated changes in serum hormone levels, and if and at what level sexual behavior reaches an asymptote in very old age. Old rhesus males (18-28 years old) whose sexual performance and hormone levels we have monitored since 1970 provide us with a unique opportunity to determine the physiological and psychological correlates of sexual behavior in an aging population of nonhuman primates.

本研究计划的长期目标是确定

项目成果

Sexual behavior in adult gonadectomized female pseudohermaphrodite, female, and male rhesus macaques (Macaca mulatta) treated with estradiol benzoate and testosterone propionate.

用苯甲酸雌二醇和丙酸睾酮治疗的成年性腺切除的雌性假两性猕猴、雌性和雄性恒河猴（Macaca mulatta）的性行为。

• DOI: 10.1037/h0077923
• 发表时间: 1982
• 期刊: Journal of comparative and physiological psychology
• 作者: Phoenix,CH;Chambers,KC
• 通讯作者: Chambers,KC

Diurnal patterns of testosterone, dihydrotestosterone, estradiol, and cortisol in serum of rhesus males: relationship to sexual behavior in aging males.

雄性恒河猴血清中睾酮、二氢睾酮、雌二醇和皮质醇的昼夜模式：与老年雄性性行为的关系。

• DOI: 10.1016/0018-506x(81)90006-4
• 发表时间: 1981
• 期刊: Hormones and behavior
• 影响因子: 3.5
• 作者: Chambers,KC;Phoenix,CH
• 通讯作者: Phoenix,CH

Sexual solicitation by middle-aged and old rhesus females.

中老年雌性恒河猴的性诱惑。

• DOI: 10.1016/0197-4580(86)90039-4
• 发表时间: 1986
• 期刊: Neurobiology of aging
• 影响因子: 4.2
• 作者: Phoenix,CH;Chambers,KC
• 通讯作者: Chambers,KC

Aging and primate male sexual behavior.

衰老与灵长类雄性性行为。

• DOI: 10.3181/00379727-183-42399
• 发表时间: 1986
• 期刊: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
• 作者: Phoenix,CH;Chambers,KC
• 通讯作者: Chambers,KC

Sexual behavior in old male rhesus monkeys: influence of familiarity and age of female partners.

老年雄性恒河猴的性行为：女性伴侣的熟悉程度和年龄的影响。

• DOI: 10.1007/bf01541591
• 发表时间: 1982
• 期刊: Archives of sexual behavior
• 影响因子: 3.8
• 作者: Chambers,KC;Phoenix,CH
• 通讯作者: Phoenix,CH