Marsupial genomics: antimicrobial peptides and endangered species conservation

有袋动物基因组学：抗菌肽和濒危物种保护

• 批准号: DP180102465
• 负责人: Prof Katherine Belov
• 金额: $ 33.31万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-03-05 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP180102465
• 关键词: Marsupial; genomics; antimicrobial; peptides; endangered

This project aims to use Australia’s unique biodiversity to tackle the global challenge of antimicrobial resistance. Rapid gene duplication and evolution of antimicrobial peptide genes in marsupials provide protection for joeys that are immunologically naïve in the pouch. By characterising immune genes in 10 marsupial species, this project will yield new antimicrobial peptides that can tackle superbugs. Genomic information will also be used to provide significant benefits, such as improving the long term conservation of our endangered native species in a more appropriate and cost-effective way.

该项目旨在利用澳大利亚独特的生物多样性来应对抗菌素耐药性的全球挑战。有袋类动物中快速的基因复制和抗菌肽基因的进化为袋子里免疫幼稚的乔伊提供了保护。通过对10种有袋类动物的免疫基因进行表征，该项目将产生能够对付超级细菌的新的抗菌肽。基因组信息也将被用来提供显著的好处，例如以更适当和更具成本效益的方式改善对濒危本土物种的长期保护。