From the pouch to the grave: age and sex related changes in immunity in the Tasmanian devil

从育儿袋到坟墓：塔斯马尼亚恶魔的免疫力与年龄和性别相关的变化

• 批准号: DP140103260
• 负责人: Prof Katherine Belov
• 金额: $ 33.69万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140103260
• 关键词: pouch; grave; age; sex; related

Tasmanian devils face extinction in the wild due to the emergence of a contagious cancer: Devil Facial Tumour Disease (DFTD). A comprehensive understanding of the devil immune system is necessary to better understand the disease and develop a vaccine against it. This project will characterise immune responses of healthy devils throughout life, from the pouch, to onset of puberty, to old age. This project will then compare these responses in DFTD-affected devils to determine why DFTD affects older animals first and does not affect sexually-immature devils. Additional outcomes will include the development of novel antibiotics against human and animal diseases and an atlas of devil development using the latest imaging technologies.

袋獾在野外面临灭绝，因为出现了一种传染性癌症：魔鬼面部肿瘤病（DFTD）。全面了解魔鬼的免疫系统是更好地了解疾病和开发疫苗的必要条件。该项目将在整个生命周期中观察健康魔鬼的免疫反应，从育儿袋，到青春期开始，再到老年。然后，该项目将比较DFTD影响的魔鬼的这些反应，以确定为什么DFTD首先影响老年动物，而不影响性不成熟的魔鬼。其他成果将包括开发针对人类和动物疾病的新型抗生素，以及使用最新成像技术的魔鬼发展地图集。