BLOOD PRESSURE AND TEMPERATURE IN AGING

衰老过程中的血压和体温

• 批准号: 3118319
• 负责人: F. EUGENE YATES
• 金额: $ 23.61万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-08-01 至 1990-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3118319
• 关键词: aging; bioperiodicity; blood pressure; body physical activity; body temperature; cardiovascular disorder epidemiology; circadian rhythms; computer graphics /printing; data collection methodology /evaluation; heart rate; human old age (65+); hypertension; mathematical model; monitoring device; sleep; statistics /biometry; wakefulness; young adult human (21-34)

LONG TERM OBJECTIVES: This Project seeks to define normative aging of the cardiovascular system by means of dynamic analysis of blood pressure and core temperature variations observed by 24 h ambulatory monitoring. Ultradian rhythms of systolic blood pressure (SBP) will be tested as markers of normative aging in well old subjects aged 60 years or older who are leading active lives in the community. Methods of linear and nonlinear spectroscopy will be used to extract circadian and ultradian rhythms. Our SPECIFIC AIM is to test the hypothesis that intrinsic aging leads to a shift in temporal organization away from circadian and toward ultradian periods. We conjecture that the fundamental ultradian period exposed by aging is the thermal equilibrium time of 3 h. We further hypothesize that progressive dynamic instability in aging leads to a tightening of the coupling between cardiovascular pressure potential variations and metabolic-thermal processes in the ultradian domain. Isolated systolic hypertension emerges as a dynamic disease based in part on that tightening or increasing "dynamic rigidity". CLINICAL IMPLICATIONS: This study will provide needed norms for systolic pressure over the course of aging in well cohorts. Furthermore, the postulated (and already observed) ultradian rhythms of SBP can serve as a new marker of cardiovascular age in normotensive subjects.

长期目标：该项目旨在定义 心血管系统的正常老化 血压和核心温度的动态分析 24小时动态监测观察到的变化。 奥特迪安 收缩压（SBP）节律将作为标记进行测试 60 岁或以上的老年受试者的正常衰老情况 在社区中过着积极的生活。 线性方法和 非线性光谱将用于提取昼夜节律和 超电律节律。 我们的具体目标是检验假设 内在衰老导致时间组织的转变 从昼夜节律到超昼夜节律。 我们推测 老化暴露的基本超电周期是热 平衡时间3小时。 我们进一步假设进步 老化过程中的动态不稳定性导致联轴器紧固 心血管压力潜在变化和 超电域的代谢热过程。 孤立 收缩期高血压作为一种动态疾病出现，部分基于 关于收紧或增加“动态刚性”。 临床意义：这项研究将提供所需的规范 健康人群衰老过程中的收缩压。 此外，假设的（和已经观测到的）超电 收缩压节律可以作为心血管年龄的新标志 在血压正常的受试者中。