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BLOOD PRESSURE AND TEMPERATURE IN AGING

衰老过程中的血压和体温

基本信息

批准号：
3118322
负责人：
F. EUGENE YATES
金额：
$ 17.81万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
1987
资助国家：
美国
起止时间：
1987-08-01 至 1990-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3118322
关键词：
aging bioperiodicity blood pressure body physical activity body temperature cardiovascular disorder epidemiology circadian rhythms computer graphics /printing data collection methodology /evaluation heart rate human old age (65+) hypertension mathematical model monitoring device sleep statistics /biometry wakefulness young adult human (21-34)

项目摘要

LONG TERM OBJECTIVES: This Project seeks to define normative aging of the cardiovascular system by means of dynamic analysis of blood pressure and core temperature variations observed by 24 h ambulatory monitoring. Ultradian rhythms of systolic blood pressure (SBP) will be tested as markers of normative aging in well old subjects aged 60 years or older who are leading active lives in the community. Methods of linear and nonlinear spectroscopy will be used to extract circadian and ultradian rhythms. Our SPECIFIC AIM is to test the hypothesis that intrinsic aging leads to a shift in temporal organization away from circadian and toward ultradian periods. We conjecture that the fundamental ultradian period exposed by aging is the thermal equilibrium time of 3 h. We further hypothesize that progressive dynamic instability in aging leads to a tightening of the coupling between cardiovascular pressure potential variations and metabolic-thermal processes in the ultradian domain. Isolated systolic hypertension emerges as a dynamic disease based in part on that tightening or increasing "dynamic rigidity". CLINICAL IMPLICATIONS: This study will provide needed norms for systolic pressure over the course of aging in well cohorts. Furthermore, the postulated (and already observed) ultradian rhythms of SBP can serve as a new marker of cardiovascular age in normotensive subjects.

长期目标：本项目旨在定义心血管系统的正常老化，血压和核心温度的动态分析通过24小时动态监测观察到的变化。超昼夜将检测收缩压（SBP）节律作为标志物在60岁或以上的老年受试者中，在社区里过着积极的生活。线性和非线性光谱学将用于提取昼夜节律，超昼夜节律我们的具体目标是检验这一假设内在的老化导致了时间组织的转变从昼夜节律到超昼夜节律。我们推测老化暴露的基本超日周期是热周期，平衡时间为3 h。我们进一步假设，老化中的动态不稳定性导致耦合的收紧心血管压力潜在变化之间的关系，超日界的代谢热过程。分离收缩期高血压是一种动力性疾病，加强或增加“动态刚性”。临床意义：本研究将提供所需的规范在健康人群中随着年龄的增长收缩压的变化。此外，假设的（和已经观察到的）超日体收缩压节律可作为心血管年龄的新标志血压正常的受试者。