CELLULAR ACTIVATION

拟议的工作是为了研究产品之间的相互作用， 各种形式的抗原刺激的免疫活性细胞和其它细胞类型 细胞介导的免疫。 我们目前的工作将集中在小鼠模型。 我们 将研究异常菌株（如NZB/W）的淋巴因子产生 老鼠. 在这种动物中，对DNA和其他抗原的反应性降低 关于迟发型超敏反应。 这种低反应性可以纠正 在体内进行了实验 我们将确定缺陷是否在 MIF和/或趋化因子产生水平。 其他实验将 专注于体内趋化事件的检测。 这里使用的模型 包括将抗原或前体介导物安装到腹膜内 腔和确定各种类型的炎症细胞的动力学。 在涉及生产调解人的研究中，我们将支付特别费用， 注意辅助辅助细胞如巨噬细胞的作用。 我们 将从不同的细胞中确定这种吞噬细胞的相对能力 来源来扮演这样的角色，并试图确定其机制 这种相互作用发生。

The proposed work is designed to study the interactions between the products of antigen-stimulated immunocompetent cells and other cell types in various forms of cell-mediated immunity. Our current work will focus on murine models. We will investigate lymphokine production in abnormal strains such as the NZB/W mouse. In this animal there is diminished reactivity to DNA and other antigens with respect to delayed hypersensitivity. This hyporeactivity may be corrected with prostaglandins in vivo. We will determine whether the defect is at the level of MIF and/or chemotactic factor production. Additional experiments will focus on the detection of chemotactic events in vivo. The model to be used here involves the installation of antigen or performed mediator into the peritoneal cavity and determining the kinetics of the various types of inflammatory cells. In those studies involving production of mediators, we will pay special attention to the role of ancillary helping cells such as the macrophage. We will determine the relative capacity of such phagocytic cells from various sources to serve such a role and attempt to determine the mechanism by which such interaction occurs.