T-CELL SUBPOPULATIONS IN TRANSPLANTATION IMMUNITY

移植免疫中的 T 细胞亚群

• 批准号: 3125121
• 负责人: HARVEY CANTOR
• 金额: $ 17.37万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 财政年份: 1977
• 资助国家: 美国
• 起止时间: 1977-07-01 至 1987-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3125121
• 关键词: B lymphocyte; T lymphocyte; antigen antibody reaction; bone marrow transplantation; clone cells; histocompatibility antigens; homologous transplantation; immunologic memory; immunosuppression; life cycle; macrophage; molecular site; radiation immunosuppression; spleen transplantation; surface antigens; thymus

T cells play a central role in virtually all types of immune responses. These cells trigger antibody production, initiate delayed-type hypersensitivity, generate killer cells, and in some instances, exert immunosuppressive effects. Our recent studies represent the first direct demonstration that these responses are not mediated by a single class of pluripotent T cells. Rather, this class is divisible into several subclasses, each of which is equipped to mediate a limited range of immune functions, each distinguishable by expression of different surface Ly markers. Thus, cells capable of generating killer, helper, and suppressor function are likely to fall into distinct Ly plus subclasses. These findings open a new areas of research which has important theoretical and practical implications. For example, studies of the relationships among the Ly plus T-cell subclasses will yield new information concerning the differentiative process resulting in the formation of immunocompetent T cells. Insight provided from these studies into the patterning of normal T cell differentiation will provide a basis for investigation of the clinical difficulties encountered in both transplantation of organs and bone marrow cells.

T 细胞在几乎所有类型的免疫反应中都发挥着核心作用。 这些 细胞触发抗体产生，引发迟发型超敏反应， 产生杀伤细胞，并在某些情况下发挥免疫抑制作用。 我们最近的研究首次直接证明了这些反应 不是由单一类别的多能 T 细胞介导的。 而是这个类 可以分为几个子类，每个子类都可以调解一个 免疫功能范围有限，每种功能可通过表达来区分 不同的表面 Ly 标记。 因此，细胞能够产生杀伤细胞、辅助细胞、 和抑制功能可能属于不同的 Ly+ 亚类。 这些发现开辟了一个新的研究领域，具有重要的理论和意义。 实际影响。 例如，Ly 与 T 细胞亚类之间关系的研究 将产生有关导致差异化过程的新信息 免疫活性T细胞的形成。 这些研究提供的见解 正常 T 细胞分化的模式将为 两种移植中遇到的临床困难的调查 器官和骨髓细胞。