REGULATION OF REAGINIC ANTIBODY RESPONSE
REGULATION OF REAGINIC ANTIBODY RESPONSE
批准号:
3124922
负责人:
KIMISHIGE ISHIZAKA
金额:
$24.93万
依托单位国家:
美国
项目类别:
财政年份:
1990
资助国家:
美国
项目状态:
已结题
起止时间:
1990-02-01 至 1992-01-31
中文摘要
本研究的目的是阐明其机制
英文摘要
The purpose of this research is to elucidate the mechanisms
involved in the regulation of the IgE response, and to find some
maneuvors to suppress the IgE antibody formation to allergens.
During the current grant period, we found that a lipocortin-like
lymphokine, i.e., glycosylation inhibiting factor (GIF), suppressed
the primary IgE and IgG antibody responses in the mouse, and
diminished the on-going IgE antibody formation. Analysis of
cellular mechanisms for the immunosuppression indicated that
GIF facilitated the generation of antigen-specific suppressor T
cells which formed their own GIF. In the present proposal,
attempts will be made to generate antigen-specific suppressor T
cells in vitro from antigen-primed T cells, and to elucidate the
cellular and molecular mechanisms involved. Experiments will be
carried out to determine whether GIF may change the function of
antigen-primed T cells, and may affect the antigen-presenting
cells. It was also shown that antigen-specific suppressor T cells
form GIF which has affinity for the antigen, and that the antigen-
specific GIF suppresses the in vivo antibody response in a carrier-
specific manner. Mouse T cell hybridomas were constructed from
an ovalbumin-primed mouse T cell clone. One of the T cell
hybridomas form antigen-specific GIF upon incubation with
antigen-pulsed syngenic macrophages. In this proposal, antigen-
specific GIF will be obtained from the T cell hybridomas, and
physicochemical properties of the molecules will be
characterized. Comparisons will be made between the antigen-
specific GIF and antigen-specific T suppressor factor (TsF)
described by other investigators. Analysis will be made to
determine whether the MHC compatibility between the cell
source of antigen-specific GIF and target cells is essential for the
carrier-specific suppression. Based on the findings obtained in
mouse lymphocyte systems, attempts will be made to generate
antigen-specific suppressor T cells in vitro from the peripheral
blood T cells of allergic patients, and to construct human antigen-
specific T cell hybridomas which will produce allergen-specific
GIF that may suppress the antibody response to the allergen.
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A method to generate antigen-specific suppressor T cells in vitro from peripheral blood T cells of honey bee venom-sensitive, allergic patients.
一种从对蜂毒敏感、过敏的患者的外周血 T 细胞中体外生成抗原特异性抑制 T 细胞的方法。
DOI:
10.1016/0022-1759(90)90072-4
发表时间:
1990
期刊:
Journal of immunological methods
影响因子:
2.2
作者:
[Carini,C, Iwata,M, Warner,J, Ishizaka,K]
通讯作者:
Ishizaka,K
IL-4-producing murine T helper cell line provides help for in vitro production of IgE.
产生 IL-4 的鼠 T 辅助细胞系为 IgE 的体外生产提供帮助。
DOI:
10.1159/000235474
发表时间:
1991
期刊:
International archives of allergy and applied immunology
影响因子:
--
作者:
[Poulsen,LK, Katamura,K, Ishizaka,K]
通讯作者:
Ishizaka,K
Lymphocytes bearing Fc receptor for IgE. VIII. Affinity of mouse IgE for Fc epsilon R on Mouse B lymphocytes.
携带 IgE Fc 受体的淋巴细胞。
DOI:
--
发表时间:
1982
期刊:
Journal of immunology (Baltimore, Md. : 1950)
影响因子:
--
作者:
[Vander-Mallie,R, Ishizaka,T, Ishizaka,K]
通讯作者:
Ishizaka,K
DOI:
--
发表时间:
1982
期刊:
Journal of immunology (Baltimore, Md. : 1950)
影响因子:
--
作者:
[Uede,T, Ishizaka,K]
通讯作者:
Ishizaka,K
Enhancement of mast cell differentiation in vitro by T cell factor(s).
T 细胞因子在体外增强肥大细胞分化。
DOI:
10.1159/000232853
发表时间:
1981
期刊:
International archives of allergy and applied immunology
影响因子:
--
作者:
[Ginsburg,H, Olson,EC, Huff,TF, Okudaira,H, Ishizaka,T]
通讯作者:
Ishizaka,T
共 31 条
SMALL INSTRUMENTATION GRANT
-
批准号:2073648
-
项目类别:
-
资助金额:$0.89万
-
财政年份:1994
-
负责人:KIMISHIGE ISHIZAKA
-
依托单位:
SMALL INSTRUMENTATION GRANT
-
批准号:3523669
-
项目类别:
-
资助金额:$0.89万
-
财政年份:1992
-
负责人:KIMISHIGE ISHIZAKA
-
依托单位:
BIOMEDICAL RESEARCH SUPPORT GRANT
-
批准号:3517636
-
项目类别:
-
资助金额:$0.65万
-
财政年份:1991
-
负责人:KIMISHIGE ISHIZAKA
-
依托单位:
ONTOGENY AND DIFFERENTIATION OF IGE-B-LYMPHOCYTES
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批准号:2060116
-
项目类别:
-
资助金额:$19.0万
-
财政年份:1989
-
负责人:KIMISHIGE ISHIZAKA
-
依托单位:
ONTOGENY AND DIFFERENTIATION OF IGE-B LYMPHOCYTES
-
批准号:3480802
-
项目类别:
-
资助金额:$15.53万
-
财政年份:1989
-
负责人:KIMISHIGE ISHIZAKA
-
依托单位:
ONTOGENY AND DIFFERENTIATION OF IGE-B LYMPHOCYTES
-
批准号:3480798
-
项目类别:
-
资助金额:$16.45万
-
财政年份:1989
-
负责人:KIMISHIGE ISHIZAKA
-
依托单位:
ONTOGENY AND DIFFERENTIATION OF IGE-B LYMPHOCYTES
-
批准号:3480803
-
项目类别:
-
资助金额:$18.18万
-
财政年份:1989
-
负责人:KIMISHIGE ISHIZAKA
-
依托单位:
ONTOGENY AND DIFFERENTIATION OF IGE-B LYMPHOCYTES
-
批准号:3480805
-
项目类别:
-
资助金额:$4.88万
-
财政年份:1989
-
负责人:KIMISHIGE ISHIZAKA
-
依托单位:
ONTOGENY AND DIFFERENTIATION OF IGE-B LYMPHOCYTES
-
批准号:3480804
-
项目类别:
-
资助金额:$18.9万
-
财政年份:1989
-
负责人:KIMISHIGE ISHIZAKA
-
依托单位:
ONTOGENY AND DIFFERENTIATION OF IGE-B-LYMPHOCYTES
-
批准号:2060117
-
项目类别:
-
资助金额:$19.77万
-
财政年份:1989
-
负责人:KIMISHIGE ISHIZAKA
-
依托单位:
CELLULAR & MOLECULAR MECH OF INFLAMMATORY REACTIONS
-
批准号:3531024
-
项目类别:
-
资助金额:$23.13万
-
财政年份:1982
-
负责人:KIMISHIGE ISHIZAKA
-
依托单位:
CELLULAR AND MOLECULAR MECHANISMS OF IMMUNE INFLAMMATORY
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批准号:3531022
-
项目类别:
-
资助金额:$28.23万
-
财政年份:1982
-
负责人:KIMISHIGE ISHIZAKA
-
依托单位:
CELLULAR & MOLECULAR MECH OF INFLAMMATORY REACTIONS
-
批准号:3531025
-
项目类别:
-
资助金额:$32.6万
-
财政年份:1982
-
负责人:KIMISHIGE ISHIZAKA
-
依托单位:
REGULATION OF REAGINIC ANTIBODY RESPONSE
-
批准号:3124920
-
项目类别:
-
资助金额:$25.86万
-
财政年份:1978
-
负责人:KIMISHIGE ISHIZAKA
-
依托单位:
ONTOGENY AND DIFFERENTIATION OF IGE-B LYMPHOCYTES
-
批准号:3480797
-
项目类别:
-
资助金额:$13.13万
-
财政年份:1978
-
负责人:KIMISHIGE ISHIZAKA
-
依托单位:
ONTOGENY AND DIFFERENTIATION OF IGE-B LYMPHOCYTES
-
批准号:3125885
-
项目类别:
-
资助金额:$11.68万
-
财政年份:1978
-
负责人:KIMISHIGE ISHIZAKA
-
依托单位:
REGULATION OF REAGINIC ANTIBODY RESPONSE
-
批准号:3124919
-
项目类别:
-
资助金额:$22.48万
-
财政年份:1978
-
负责人:KIMISHIGE ISHIZAKA
-
依托单位:
ONTOGENY AND DIFFERENTIATION OF IGE-B LYMPHOCYTES
-
批准号:3480801
-
项目类别:
-
资助金额:$8.87万
-
财政年份:1978
-
负责人:KIMISHIGE ISHIZAKA
-
依托单位:
REGULATION OF REAGINIC ANTIBODY RESPONSE
-
批准号:3124918
-
项目类别:
-
资助金额:$22.71万
-
财政年份:1978
-
负责人:KIMISHIGE ISHIZAKA
-
依托单位:
REGULATION OF REAGINIC ANTIBODY RESPONSE
-
批准号:2059771
-
项目类别:
-
资助金额:$21.89万
-
财政年份:1978
-
负责人:KIMISHIGE ISHIZAKA
-
依托单位:
海外基金