IMMUNOBIOLOGY OF THE MAJOR HISTOCOMPATIBILITY COMPLEX
主要组织相容性复合体的免疫生物学
基本信息
- 批准号:3132030
- 负责人:
- 金额:$ 12.87万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1989
- 资助国家:美国
- 起止时间:1989-04-01 至 1991-12-31
- 项目状态:已结题
- 来源:
- 关键词:Marek's disease biological polymorphism chickens gene expression genetic library genetic manipulation histocompatibility antigens laboratory mouse laboratory rabbit linkage mapping major histocompatibility complex molecular cloning neoplasm /cancer immunology nucleic acid probes nucleic acid sequence protein structure surface antigens virus infection mechanism virus related neoplasm /cancer
项目摘要
The long-term objective of the proposed research is to learn what
the avian major histocompatibility complex (MHC) can tell us about
the evolution of the MHC gene complex and the means by which this
MHC confers disease resistance. The proposed study provides an
opportunity to contrast the strucutre of a non-mammalian MHC, the
B system of the chicken, with the MHCs of mouse and man. It is
already known that one B system subregion, the B-G subregion,
encodes antigens which are differrent from known gene products
associated with the MHC of mammals. While these antigens are
highly polymorphic and their genes tightly-linked with those of the
class I and class II antigens encoded within the B system, they are
clearly different from all ohter MHC-encoded molecules. partial
sequence data derived from a B-B cDNa clone isolated in this labe
indicates that the B-G antigens contain a domain more closely
similar to immunoglobulin and T-cell receptor variable region
domains (recognition domains) than to Ig-constant region domains
such as those found within class I and class II antigens.
Another important aspect of the B system is the particularly strong
association found between the presence of the B-F/B-L subregion
genes and resistance to Marek's disease, a herpesvirus-induced
lymphoma. Hence, the B system provides a model in which to study
the relationship between the MHC and viral disease when suitable
reagents become available.
The specific aims are 1) to complete a structural analysis of the
B-G21 antigens, produce a restriction enzyme map of the B-G
gubregion and link B-G to the B-F and B-L subregions; 2) to
undertake molecular cloning of B-F21 and B-L21 genes and complete
a similar molecular genetic analysis of these B subregions which
encode the avian class I and class II-like gene counterparts, and
3) we would like to begin to apply the information learned in the
present study to the investigation of the process of infection and
tumorigenesis caused by Marek's disease virus.
拟议研究的长期目标是了解什么
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(1)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
MARCIA M MILLER其他文献
MARCIA M MILLER的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('MARCIA M MILLER', 18)}}的其他基金
Equipment for Visualization of Fragile Subcellular Detail by Electron Microscopy
通过电子显微镜观察脆弱亚细胞细节的设备
- 批准号:
7595603 - 财政年份:2009
- 资助金额:
$ 12.87万 - 项目类别:
IMMUNOBIOLOGY OF THE MAJOR HISTOCOMPATIBILITY COMPLEX
主要组织相容性复合体的免疫生物学
- 批准号:
3132026 - 财政年份:1985
- 资助金额:
$ 12.87万 - 项目类别:
IMMUNOBIOLOGY OF THE MAJOR HISTOCOMPATIBILITY COMPLEX
主要组织相容性复合体的免疫生物学
- 批准号:
3132023 - 财政年份:1985
- 资助金额:
$ 12.87万 - 项目类别:
IMMUNOBIOLOGY OF THE MAJOR HISTOCOMPATIBILITY COMPLEX
主要组织相容性复合体的免疫生物学
- 批准号:
3132021 - 财政年份:1985
- 资助金额:
$ 12.87万 - 项目类别:
IMMUNOBIOLOGY OF THE MAJOR HISTOCOMPATIBILITY COMPLEX
主要组织相容性复合体的免疫生物学
- 批准号:
3132027 - 财政年份:1985
- 资助金额:
$ 12.87万 - 项目类别:
IMMUNOBIOLOGY OF THE MAJOR HISTOCOMPATIBILITY COMPLEX
主要组织相容性复合体的免疫生物学
- 批准号:
3132029 - 财政年份:1985
- 资助金额:
$ 12.87万 - 项目类别:
IMMUNOBIOLOGY OF THE MAJOR HISTOCOMPATIBILITY COMPLEX
主要组织相容性复合体的免疫生物学
- 批准号:
3132028 - 财政年份:1985
- 资助金额:
$ 12.87万 - 项目类别:
相似海外基金
Elucidation of true ecology (biological polymorphism) of H. pylori persistently colonized in the stomach and its associated disorders
阐明胃中持续定植的幽门螺杆菌的真实生态(生物多态性)及其相关疾病
- 批准号:
20K07857 - 财政年份:2020
- 资助金额:
$ 12.87万 - 项目类别:
Grant-in-Aid for Scientific Research (C)