IMMUNOBIOLOGY OF THE MAJOR HISTOCOMPATIBILITY COMPLEX

主要组织相容性复合体的免疫生物学

基本信息

  • 批准号:
    3132030
  • 负责人:
  • 金额:
    $ 12.87万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1989
  • 资助国家:
    美国
  • 起止时间:
    1989-04-01 至 1991-12-31
  • 项目状态:
    已结题

项目摘要

The long-term objective of the proposed research is to learn what the avian major histocompatibility complex (MHC) can tell us about the evolution of the MHC gene complex and the means by which this MHC confers disease resistance. The proposed study provides an opportunity to contrast the strucutre of a non-mammalian MHC, the B system of the chicken, with the MHCs of mouse and man. It is already known that one B system subregion, the B-G subregion, encodes antigens which are differrent from known gene products associated with the MHC of mammals. While these antigens are highly polymorphic and their genes tightly-linked with those of the class I and class II antigens encoded within the B system, they are clearly different from all ohter MHC-encoded molecules. partial sequence data derived from a B-B cDNa clone isolated in this labe indicates that the B-G antigens contain a domain more closely similar to immunoglobulin and T-cell receptor variable region domains (recognition domains) than to Ig-constant region domains such as those found within class I and class II antigens. Another important aspect of the B system is the particularly strong association found between the presence of the B-F/B-L subregion genes and resistance to Marek's disease, a herpesvirus-induced lymphoma. Hence, the B system provides a model in which to study the relationship between the MHC and viral disease when suitable reagents become available. The specific aims are 1) to complete a structural analysis of the B-G21 antigens, produce a restriction enzyme map of the B-G gubregion and link B-G to the B-F and B-L subregions; 2) to undertake molecular cloning of B-F21 and B-L21 genes and complete a similar molecular genetic analysis of these B subregions which encode the avian class I and class II-like gene counterparts, and 3) we would like to begin to apply the information learned in the present study to the investigation of the process of infection and tumorigenesis caused by Marek's disease virus.
拟议研究的长期目标是了解什么

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(1)

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MARCIA M MILLER其他文献

MARCIA M MILLER的其他文献

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{{ truncateString('MARCIA M MILLER', 18)}}的其他基金

Equipment for Visualization of Fragile Subcellular Detail by Electron Microscopy
通过电子显微镜观察脆弱亚细胞细节的设备
  • 批准号:
    7595603
  • 财政年份:
    2009
  • 资助金额:
    $ 12.87万
  • 项目类别:
MHC Loci in the Control of Marek's Lymphoma
MHC 位点控制马立克氏淋巴瘤
  • 批准号:
    6909121
  • 财政年份:
    2004
  • 资助金额:
    $ 12.87万
  • 项目类别:
MHC Loci in the Control of Marek's Lymphoma
MHC 位点控制马立克氏淋巴瘤
  • 批准号:
    6821450
  • 财政年份:
    2004
  • 资助金额:
    $ 12.87万
  • 项目类别:
IMMUNOBIOLOGY OF THE MAJOR HISTOCOMPATIBILITY COMPLEX
主要组织相容性复合体的免疫生物学
  • 批准号:
    3132026
  • 财政年份:
    1985
  • 资助金额:
    $ 12.87万
  • 项目类别:
IMMUNOBIOLOGY OF THE MAJOR HISTOCOMPATIBILITY COMPLEX
主要组织相容性复合体的免疫生物学
  • 批准号:
    3132023
  • 财政年份:
    1985
  • 资助金额:
    $ 12.87万
  • 项目类别:
IMMUNOBIOLOGY OF THE MAJOR HISTOCOMPATIBILITY COMPLEX
主要组织相容性复合体的免疫生物学
  • 批准号:
    3132021
  • 财政年份:
    1985
  • 资助金额:
    $ 12.87万
  • 项目类别:
IMMUNOBIOLOGY OF THE MAJOR HISTOCOMPATIBILITY COMPLEX
主要组织相容性复合体的免疫生物学
  • 批准号:
    3132027
  • 财政年份:
    1985
  • 资助金额:
    $ 12.87万
  • 项目类别:
IMMUNOBIOLOGY OF THE MAJOR HISTOCOMPATIBILITY COMPLEX
主要组织相容性复合体的免疫生物学
  • 批准号:
    3132029
  • 财政年份:
    1985
  • 资助金额:
    $ 12.87万
  • 项目类别:
IMMUNOBIOLOGY OF THE MAJOR HISTOCOMPATIBILITY COMPLEX
主要组织相容性复合体的免疫生物学
  • 批准号:
    3132028
  • 财政年份:
    1985
  • 资助金额:
    $ 12.87万
  • 项目类别:

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  • 批准号:
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