ACQUIRED IMMUNODEFICIENCY DISEASE IN HAITIAN CHILDREN

在迈阿密出生的海地婴儿有获得性免疫缺陷的证据 疾病综合征(艾滋病)和发展相关的多种严重感染 T细胞亚群、免疫复合物和升高的免疫球蛋白显著逆转 级别。提出了一个案例研究来定义这一自然历史。 为制定疾病的预后参数以及提供依据 用于各种形式的干预措施的收益-风险分析，如药物或 与世隔绝。按照目前的病例发现率，将新增10-20例病例 每年都会入伍。病毒排泄和宿主的频率和持续时间 将监测对疱疹病毒家族选定成员的反应 纵向评估艾滋病患者与对照组在以下方面的差异 它们对常见病毒的主要反应。有证据表明，一部小说 代理导致了艾滋病。儿科患者可能提供一个最佳的来源 病原体的检测。将对艾滋病患者的组织进行研究 寻找与人类有关的整合病毒DNA序列的证据 以及与转化基因相关的序列，这些基因可能是 在组织中被激活。索引病例的家庭成员及其比较 将对家庭进行跟踪，以检测免疫异常的证据。 有T细胞亚群逆转等免疫异常的个人 然后进行前瞻性跟踪，以确定临床疾病是否为 T细胞亚群逆转或亚临床的必然后果 反常现象时有发生。一项确定相关风险因素的现场研究 随着免疫缺陷的发展，会通过家访来做 和调查问卷。索引病例和对照家庭的家庭成员 将被前瞻性地跟踪以确定获得性 家庭单位的免疫缺陷。作为获取试点数据的手段 免疫缺陷的传播，怀孕的艾滋病妇女，怀孕的配偶 海地患有艾滋病的成年男性和指数婴儿和ALL的孕妇 他们的新生儿将接受免疫功能和病毒的研究。 排泄物。

Haitian infants born in Miami have evidence on an acquired immunodeficiency disease syndrome (AIDS) and develop multiple severe infections associated with marked reversal of T-cell subsets, immune complexes and elevated IgG levels. A case study is proposed to define the natural history of this disease and to develop prognostic parameters, as well as provide a basis for benefit-risk analysis of various forms of intervention such as drugs or isolation. At the present rate of case detection 10-20 new cases will be enlisted each year. The frequency and duration of virus excretion and host responses to selected members of the Herpesvirus family will be monitored longitudinally to assess how AIDS patients differ from comparison groups in their primary responses to common viruses. Evidence suggests that a novel agent causes AIDS. Pediatric patients may provide an optimal source for detection of etiologic agents. Tissues of AIDS patients will be studied for evidence of integrated viral DNA sequences related to human retroviruses and for sequences related to transforming genes that may be activated in tissues. Family members of index cases and comparison families will be followed to detect evidence of immunologic abnormalities. Individuals with immunologic abnormalities such as T-cell subset reversal will then be followed prospectively to determine if clinical disease is an inevitable consequence of T-cell subset reversal or if subclinical abnormalities occur. A field study to determine risk factors associated with the development of immunodeficiency will be done by home visitation and questionnaires. Family members of index cases and comparison families will be followed prospectively to determine the frequency of acquired immunodeficiency in family units. As means of obtaining pilot data on transmission of immunodeficiency, pregnant AIDS women, pregnant consorts of adult Haitian males with AIDS and pregnant mothers of index infants and all their newborn infants will be studied for immune function and for virus excretion.