INFANTS OF HTLV-III/LAV SEROPOSITIVE MOTHERS

在最近居住在迈阿密的海地移民中， HTLV-III/LAV抗体为2- 9%。 海地出生的妇女在 每年在迈阿密的杰克逊纪念医院有2200和2500名婴儿; 其中大约20名婴儿将出现临床证据， HTLV-III/LAV感染。 这些交付至少占90% 在戴德县海地移民中出生的孩子 我们建议 确定血清反应呈阳性的母亲生下下列婴儿的比例： 出现临床综合征的血清阳性、病毒阳性婴儿 与HTLV-III/LAV感染有关。 血清反应阳性和血清反应阴性 血清反应阳性母亲的婴儿将被随访， 血清反应阴性母亲的血清反应阴性婴儿两年来评估 他们的结果。 从这项基于人群的研究中获得的信息将 在两个主要领域具有重要意义。 首先，来自 母亲将被用来评估未出生婴儿的风险， HTLV-III/LAV感染。 第二，人口基础的特点， 研究将提供更完整的信息，临床谱 该人群中婴儿的HTLV-III/LAV感染。

Among recent Haitian emigrants living in Miami the prevalence of serum antibodies to HTLV-III/LAV is 2-9%. Haitian-born women deliver between 2200 and 2500 infants annually at Jackson Memorial Hospital in Miami; approximately 20 of these infants will develop clinical evidence of HTLV-III/LAV infection each year. These deliveries constitute at least 90% of all births among Haitian emigrants in Dade County. We propose to determine the proportion of seropositive mothers that give birth to seropositive, virus-positive infants that develop clinical syndromes associated with HTLV-III/LAV infection. Seropositive and seronegative infants of seropositive mothers will be followed with a comparable number of seronegative infants of seronegative mothers for two years to assess their outcome. Information obtained from this population-based study will be of significance in two major areas. First, the information from the mothers will be used to assess the risks to unborn infants of women with HTLV-III/LAV infection. Second, the population-based character of the study will provide more complete information on the clinical spectrum of HTLV-III/LAV infection among infants in this population.