Regulation of membrane trafficking by phoshorylation during cell division.

细胞分裂过程中通过磷酸化调节膜运输。

• 批准号: BB/I018921/1
• 负责人: Emmanuel Boucrot
• 金额: $ 157.31万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FI018921%2F1
• 关键词: Regulation; membrane; trafficking; phoshorylation; during

Each one of the several billions cells composing our body must divide to multiply during growth, healing or normal regeneration. Cell division is a complex event during which many of the processes happening inside each cell must be tightly controlled. For successful cell division to happen, some cellular events must be activated and others inhibited. Failure of certain key steps can lead to growth defects and anomalies and to various diseases such as cancer. The research I intend to perform aims at understanding how cells control the exchanges of their membrane between their envelope and interior. It is a very important aspect of cell division as it can, if perturbed, compromise proper cell renewal. Acquiring a global understanding of these events is desirable in order to progress in our knowledge of how cells function and to have the material to design new therapies for treating some related human diseases.

组成我们身体的数十亿个细胞中的每一个都必须在生长、愈合或正常再生过程中分裂繁殖。细胞分裂是一个复杂的过程，在此过程中，每个细胞内发生的许多过程必须受到严格控制。为了成功的细胞分裂，一些细胞事件必须被激活，而另一些则被抑制。某些关键步骤的失败可能导致生长缺陷和异常以及各种疾病，如癌症。我打算进行的研究旨在了解细胞如何控制其包膜和内部之间的膜交换。它是细胞分裂的一个非常重要的方面，因为如果受到干扰，它可以损害适当的细胞更新。获得对这些事件的全球性理解是可取的，以便在我们对细胞如何发挥作用的知识方面取得进展，并获得设计治疗某些相关人类疾病的新疗法的材料。

项目成果

Preferential invasion of mitotic cells by Salmonella reveals that cell surface cholesterol is maximal during metaphase.

沙门氏菌优先侵入有丝分裂细胞表明细胞表面胆固醇在中期达到最大。

• DOI: 10.1242/jcs.115253
• 发表时间: 2013
• 期刊: Journal of cell science
• 影响因子: 4
• 作者: Santos AJ

FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis.

• DOI: 10.1038/s41556-018-0146-8
• 发表时间: 2018-09
• 期刊: Nature cell biology
• 影响因子: 21.3
• 作者: Chan Wah Hak L;Khan S;Di Meglio I;Law AL;Lucken-Ardjomande Häsler S;Quintaneiro LM;Ferreira APA;Krause M;McMahon HT;Boucrot E
• 通讯作者: Boucrot E

Myostatin-like proteins regulate synaptic function and neuronal morphology.

• DOI: 10.1242/dev.152975
• 发表时间: 2017-07-01
• 期刊: Development (Cambridge, England)
• 作者: Augustin H;McGourty K;Steinert JR;Cochemé HM;Adcott J;Cabecinha M;Vincent A;Halff EF;Kittler JT;Boucrot E;Partridge L
• 通讯作者: Partridge L

Endophilin-A2 functions in membrane scission in clathrin-independent endocytosis.

• DOI: 10.1038/nature14064
• 发表时间: 2015-01-22
• 期刊: NATURE
• 影响因子: 64.8
• 作者: Renard, Henri-Francois;Simunovic, Mijo;Lemiere, Joel;Boucrot, Emmanuel;Garcia-Castillo, Maria Daniela;Arumugam, Senthil;Chambon, Valerie;Lamaze, Christophe;Wunder, Christian;Kenworthy, Anne K.;Schmidt, Anne A.;McMahon, Harvey T.;Sykes, Cecile;Bassereau, Patricia;Johannes, Ludger
• 通讯作者: Johannes, Ludger