The role of mechanosensitive TRP channels in arteriolar myogenic signalling and blood flow autoregulation

小动脉是调节体内血液流动的微小血管。它们由内皮细胞的内层组成，周围环绕着一层或两层肌肉细胞，这些肌肉细胞能够收缩或放松，以调节组织中的流动阻力。我们已经确定了被称为Trp通道的编码蛋白的基因在小动脉中的表达，这些基因可能会促进这些血管在血压升高时变窄，因此血流几乎不受影响。这项工作将确定小动脉中特定色氨酸通道的正常细胞分布和功能，并为未来研究疾病中血流中断提供基础。

Arterioles are microscopic blood vessels that regulate blood flow in the body. They are composed of an inner lining of endothelial cells surrounded by one or two layers of muscle cells that are able to contract or relax to regulate resistance to flow in the tissues. We have identified the expression of genes encoding proteins called TRP channels in arterioles that may promote narrowing of these vessels in response to increased blood pressure, so that flow is little affected. This work will define the normal cellular distribution and function of specific TRP channels in arterioles and should provide a basis for future studies investigating the disruption of blood flow in disease.