Improved adenoviral gene therapy vectors via combined genetic modification of the adenovirus capsid to ablate interaction with blood coagulation facto

通过对腺病毒衣壳进行联合遗传修饰以消除与凝血因子的相互作用，改进腺病毒基因治疗载体

• 批准号: BB/I53297X/1
• 负责人: Andrew Baker
• 金额: $ 23.81万
• 依托单位: University of Glasgow
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FI53297X%2F1
• 关键词: Improved; adenoviral; gene; therapy; vectors

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

目前，GtR 中尚未提供所有资助研究的摘要。这通常是因为在提交提案时不需要摘要，但可能是因为它包含个人详细信息等敏感信息。

项目成果

Defining a Novel Role for the Coxsackievirus and Adenovirus Receptor in Human Adenovirus Serotype 5 Transduction In Vitro in the Presence of Mouse Serum.

• DOI: 10.1128/jvi.02487-16
• 发表时间: 2017-06-15
• 期刊: Journal of virology
• 影响因子: 5.4
• 作者: Lopez-Gordo E;Doszpoly A;Duffy MR;Coughlan L;Bradshaw AC;White KM;Denby L;Nicklin SA;Baker AH
• 通讯作者: Baker AH

Retargeting FX-binding-ablated HAdV-5 to vascular cells by inclusion of the RGD-4C peptide in hexon hypervariable region 7 and the HI loop.

• DOI: 10.1099/jgv.0.000505
• 发表时间: 2016-08
• 期刊: The Journal of general virology
• 作者: Robertson S;Parker AL;Clarke C;Duffy MR;Alba R;Nicklin SA;Baker AH
• 通讯作者: Baker AH