Developmental Clinical Studies - Gene Therapy For Vein Graft Failure
Developmental Clinical Studies - Gene Therapy For Vein Graft Failure
批准号:
G1001147/1
负责人:
Andrew Baker
金额:
$586.5万
依托单位:
依托单位国家:
英国
项目类别:
Research Grant
财政年份:
2011
资助国家:
英国
项目状态:
未结题
起止时间:
2011 至 --
中文摘要
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英文摘要
Failure rates for heart bypass grafts using veins remain very high and represent a major clinical problem that lacks a drug-based treatment. Our prior studies have demonstrated the unique ability of gene therapy (the use of a patient s genes to treat the disease) to prevent the vein getting blocked which is associated with graft failure. We wish to perform a clinical trial in patients undergoing bypass grafting and assess the safety and beneficial effect of gene therapy.
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Activation of long non-coding RNA by a gene therapy CRISPR/Cas9 approach to prevent vein graft failure
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批准号:EP/X024563/1
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LADUMA: Reaching the Highest Redshifts with the Deepest HI Survey
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批准号:2308161
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Collaborative Research: Investigating the genomic basis of key performance traits to quantify the evolutionary potential of coral populations under climate change
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批准号:2023155
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资助金额:$18.6万
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财政年份:2021
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依托单位:
Collaborative Research: Assessing the changing symbiotic milieu on Caribbean coral reefs under climate change: magnitude, tradeoffs, interventions, and implications
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批准号:1851392
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项目类别:Continuing Grant
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资助金额:$49.46万
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财政年份:2019
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负责人:Andrew Baker
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依托单位:
Collaborative Research: Observing the Cosmic Evolution of Neutral Hydrogen
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批准号:1814421
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项目类别:Standard Grant
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资助金额:$33.69万
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财政年份:2018
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负责人:Andrew Baker
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依托单位:
REU Site: Physics and Astronomy Research at Rutgers
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批准号:1560077
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项目类别:Continuing Grant
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资助金额:$29.94万
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财政年份:2016
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负责人:Andrew Baker
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依托单位:
Adenovirus and coagulation factor interactions and the impact on virus stability and utility for gene therapy
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批准号:BB/L027933/1
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项目类别:Research Grant
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资助金额:$59.68万
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财政年份:2015
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负责人:Andrew Baker
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依托单位:
Adenovirus and coagulation factor interactions and the impact on virus stability and utility for gene therapy
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批准号:BB/L027933/2
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项目类别:Research Grant
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资助金额:$46.15万
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财政年份:2015
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负责人:Andrew Baker
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依托单位:
RAPID: Collaborative Research: Are Eastern Tropical Pacific reefs becoming more resilient to ENSO?
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批准号:1447306
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项目类别:Standard Grant
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资助金额:$8.46万
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财政年份:2014
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负责人:Andrew Baker
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依托单位:
New insights into the response of reef corals to climate change using the symbiont to host cell ratio as a metric of bleaching susceptibility
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批准号:1358699
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项目类别:Standard Grant
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资助金额:$63.88万
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财政年份:2014
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负责人:Andrew Baker
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依托单位:
TRANSLATING HUMAN EMBRYONIC STEM CELL-DERIVED ENDOTHELIAL CELL THERAPY TO THE CLINIC
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批准号:MR/K00719X/1
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项目类别:Research Grant
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资助金额:$152.33万
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财政年份:2013
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负责人:Andrew Baker
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依托单位:
REU Site: Physics and Astronomy at Rutgers - the On-Ramp at Exit 9
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批准号:1263280
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项目类别:Continuing Grant
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资助金额:$27.26万
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财政年份:2013
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负责人:Andrew Baker
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依托单位:
Refinement and assessment of a novel adenovirus targeting platform for application to human gene therapy
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批准号:BB/I005927/1
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项目类别:Research Grant
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资助金额:$48.81万
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财政年份:2011
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负责人:Andrew Baker
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依托单位:
U.S.- South Africa Collaboration: Catalyzing a Deep Neutral Hydrogen Survey with MeerKAT
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批准号:1132987
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项目类别:Standard Grant
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资助金额:$4.54万
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财政年份:2011
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负责人:Andrew Baker
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依托单位:
Improved adenoviral gene therapy vectors via combined genetic modification of the adenovirus capsid to ablate interaction with blood coagulation facto
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批准号:BB/I53297X/1
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项目类别:Research Grant
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资助金额:$23.81万
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财政年份:2011
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负责人:Andrew Baker
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依托单位:
CAREER: The Cosmic Evolution of Dense Gas in Star-Forming Galaxies
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批准号:0955810
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项目类别:Continuing Grant
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资助金额:$67.51万
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财政年份:2010
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负责人:Andrew Baker
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依托单位:
Evaluating the impact of coagulation factors on gene delivery using pseudotyped adenoviruses: receptor usage bioavailability and immunogenicity
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批准号:BB/E02145X/2
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项目类别:Research Grant
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资助金额:$3.08万
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财政年份:2009
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负责人:Andrew Baker
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依托单位:
Interrogation of the adenovirus hexon: A new paradigm for virus biology and application to therapeutic gene delivery
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批准号:BB/G016844/1
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项目类别:Research Grant
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资助金额:$87.94万
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财政年份:2009
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负责人:Andrew Baker
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依托单位:
Evaluating the impact of coagulation factors on gene delivery using pseudotyped adenoviruses: receptor usage bioavailability and immunogenicity
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批准号:BB/E020844/1
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项目类别:Research Grant
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资助金额:$24.08万
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财政年份:2007
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负责人:Andrew Baker
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依托单位:
Nowhere Left to Hide: Closing in on Dusty Galaxies at High Redshift
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批准号:0708653
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项目类别:Continuing Grant
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资助金额:$29.19万
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财政年份:2007
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负责人:Andrew Baker
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依托单位:
国内基金
海外基金
Molecular Interaction Reconstruction of Rheumatoid Arthritis Therapies Using Clinical Data
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批准号:31070748
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项目类别:面上项目
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资助金额:34.0万元
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批准年份:2010
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负责人:Christine Nardini
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依托单位: