FACTORS INFLUENCING BONE METABOLISM

影响骨代谢的因素

• 批准号: 3154969
• 负责人: Lawrence Gideon Raisz
• 金额: $ 29.06万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 1975
• 资助国家: 美国
• 起止时间: 1975-03-01 至 1990-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3154969
• 关键词: 25 hydroxycholecalciferol; acid base balance; arachidonate; bioassay; biological models; blood chemistry; bone development; bone metabolism; bone metabolism disorder; calcification; calcitonin; carbonic anhydrase inhibitors; cell population study; chromatography; collagen; connective tissue metabolism; diphosphonate; electron microscopy; glucocorticoids; guinea pigs; hormone regulation /control mechanism; host neoplasm interaction; human subject; hydroxyproline; hypocalcemia; laboratory mouse; laboratory rat; lymphoma; lysosomes; microphthalmos; molecular pathology; multiple myeloma; mutant; organ culture; orphan disease /drug; osteoclast activating factor; osteocytes; osteopetrosis; parathyroid hormones; pathologic bone resorption; physiologic bone resorption; prostaglandins; protein biosynthesis; radiography; radiotracer; scintillation counter; sex hormones; skeletal pharmacology; vitamin D

The regulation of bone resorption and formation by systemic hormones and local factors will be studied using animal models and organ and cell cultures. The effects of local factors including prostaglandins, macromolecular stimulators and inhibitors of bone resorption will be examined. The products of arachidonic acid metabolism in bone will be characterized and the effects of eiconsanoids on bone formation analyzed. The relation of local stimulators and inhibitors to osteoclast activating factor and other stimulators of bone resorption will be examined both chemically and biologically. Studies on systemic hormones will include analysis of the anabolic effect of PTH, the paradoxical osteomalacia produced by toxic doses of 1,25-(OH)2D and studies on the mechanism of escape from calcitonin. Glucocorticoids will be analyzed for their dual effects and for their relation to changes in endogenous prostaglandin production. New models will be developed for the study of hormonal regulation of mineralization and for the analysis of the role of sex hormones in bone metabolism. These studies are intended to increase our understanding of physiologic and pathologic regulation of bone metabolism and to provide new insight in the pathogenesis of metabolic bone disease.

全身激素对骨吸收和骨形成的调节， 将使用动物模型和器官和细胞研究局部因素 cultures. 当地因素的影响， 骨吸收的大分子刺激剂和抑制剂将是 考察 骨中花生四烯酸代谢的产物将 表征并分析了Eiconsanoids对骨形成的影响。 破骨细胞激活与局部刺激因子和抑制因子的关系 因素和其他刺激骨吸收将检查 从化学和生物学上来说。 对全身激素的研究将包括 甲状旁腺素的合成代谢作用分析，反常的骨软化症 毒性剂量1，25-（OH）_2D产生的放射性核素及其作用机理的研究 逃离降钙素 将分析糖皮质激素的双重 影响及其与内源性前列腺素变化的关系 生产 将开发新的模型用于研究激素 调节矿化和分析性别的作用 激素在骨代谢中的作用 这些研究旨在提高我们的 了解骨代谢的生理和病理调节 并为代谢性骨病的发病机制提供新的见解。