Regulation of DNA synthesis and host evasion by Lentivirus Capsids

该项目旨在研究一种病毒，例如HIV，如何在宿主细胞的细胞质中合成DNA，而不会在细胞核外检测到DNA时触发细胞的先天免疫。它有望促进对病毒蛋白质外壳在感染过程中调节DNA合成的作用的理解。 该项目的成果应包括提高澳大利亚的基本病毒和细胞生物学研究能力。该项目预计将为向细胞输送基因的新工具做出贡献，从而使治疗和生物技术应用受益。

This project aims to investigate how a type of virus, exemplified by HIV, can synthesise DNA in the cytoplasm of a host cell, without triggering the cell’s innate immunity when DNA is detected outside the nucleus. It expects to advance understanding of the role of the virus’ protein shell in regulating DNA synthesis during infection. The project outcomes should include enhanced capacity for fundamental virus and cell biology research in Australia. The project anticipates contributing to new tools for delivering genes to cells, benefiting therapeutic and biotechnology applications.