Lentiviral infection: intracellular immunity and viral evasion

我是一名生物化学家，专注于回答这样一个问题：为什么人类容易感染艾滋病毒，而某些猴子对艾滋病毒具有抵抗力？众所周知，这些猴子进化出了可以靶向并摧毁病毒的蛋白质，但同等的人类蛋白质对艾滋病毒没有作用。我打算比较猴子和人类的蛋白质，以了解猴子是如何摧毁病毒的，以及为什么人类蛋白质有缺陷。这些研究将为下一代艾滋病毒治疗提供信息。

I am a biochemist focused on answering the question: why is it that humans are susceptible to HIV infection, while certain monkeys are resistant? It is known that these monkeys have evolved proteins which can target and destroy the virus, but the equivalent human proteins don’t work against HIV. I intend to compare the monkey and human proteins to understand how the monkeys destroy the virus and why the human protein is defective. These studies will inform the next generation of HIV treatment.