ANTIGEN PROCESSING GENES AND CELL BIOLOGY
抗原加工基因和细胞生物学
基本信息
- 批准号:3145535
- 负责人:
- 金额:$ 19.49万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1991
- 资助国家:美国
- 起止时间:1991-01-01 至 1995-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION: (Adapted from the applicant's abstract) The overall objective
of this project is to elucidate pathways by which antigen presenting cells
process exogenous antigens for presentation to T cells. The specific aims
are: 1) to characterize the defects in B cell line mutants which are
unable to present HLA class II restricted antigens to antigen specific T
cells; 2) to clone genes involved in antigen processing; 3) to investigate
the "occupancy" hypothesis for the effect of mutations in antigen
processing genes on the conformation of HLA class II molecules; and 4) to
study combined immunodeficiency patients for defects in antigen processing.
The basic strategy for cloning antigen processing genes will be to
transfect various cloned genes and gene libraries into the
antigen-processing mutants and to select for mutants whose defect has been
complemented by the introduced DNA. Immunomicroscopic and biochemical
approaches will be used to characterize the defects in antigen processing
mutants. The "occupancy" hypothesis will be tested by binding studies of
peptides to class II molecules from antigen processing mutants. Cell lines
from patients with combined immunodeficiency of unknown etiology will be
analyzed for defects in antigen processing. It is anticipated that
detailed characterization of the basic defects in these mutants and the
cloning of the normal homologues of their mutant genes, as proposed here,
will yield important information on antigen processing, on class II
biosynthesis and expression, and on the nature of allorecognition.
描述:(改编自申请人的摘要)总体目标
该项目的主要目的是阐明抗原提呈细胞
处理外源抗原以呈递给T细胞。具体目标
1)鉴定B细胞系突变体的缺陷,这些缺陷
无法将人类白细胞抗原II类限制性抗原呈递给抗原特异性T细胞
细胞;2)克隆与抗原加工有关的基因;3)研究
抗原突变效应的“占有性”假说
处理基因对人类白细胞抗原II类分子构象的影响;以及4)
研究联合免疫缺陷患者的抗原处理缺陷。
克隆抗原处理基因的基本策略将是
将各种克隆的基因和基因库导入
抗原处理突变体,并筛选其缺陷已被
辅以引入的DNA。免疫显微镜和生化
将使用方法来表征抗原处理过程中的缺陷。
变种人。“占有率”假说将通过以下约束性研究进行检验
从抗原处理突变体中将多肽转化为II类分子。细胞系
来自不明原因的联合免疫缺陷患者
分析抗原处理过程中的缺陷。预计
这些突变体的基本缺陷的详细特征以及
克隆它们的突变基因的正常同源基因,如这里所建议的,
将提供有关抗原处理的重要信息,关于II类
生物合成和表达,以及同种异体识别的性质。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
DONALD A PIOUS其他文献
DONALD A PIOUS的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('DONALD A PIOUS', 18)}}的其他基金
相似海外基金
Modulation of T lymphocyte Activation by Ã2-Adrenergic Receptor Signalling Pathways
α2-肾上腺素能受体信号通路对 T 淋巴细胞激活的调节
- 批准号:
RGPIN-2019-06980 - 财政年份:2022
- 资助金额:
$ 19.49万 - 项目类别:
Discovery Grants Program - Individual
A precision tumor neoantigen identification pipeline for cytotoxic T-lymphocyte-based cancer immunotherapies
用于基于细胞毒性 T 淋巴细胞的癌症免疫疗法的精准肿瘤新抗原识别流程
- 批准号:
10581488 - 财政年份:2022
- 资助金额:
$ 19.49万 - 项目类别:
Modulation of T lymphocyte Activation by ß2-adrenergic Receptor Signalling Pathways
α2-肾上腺素能受体信号通路对 T 淋巴细胞激活的调节
- 批准号:
574979-2022 - 财政年份:2022
- 资助金额:
$ 19.49万 - 项目类别:
University Undergraduate Student Research Awards
A precision tumor neoantigen identification pipeline for cytotoxic T-lymphocyte-based cancer immunotherapies
用于基于细胞毒性 T 淋巴细胞的癌症免疫疗法的精准肿瘤新抗原识别流程
- 批准号:
10332251 - 财政年份:2022
- 资助金额:
$ 19.49万 - 项目类别:
Modulation of T lymphocyte Activation by Ã2-adrenergic Receptor Signalling Pathways
α2-肾上腺素能受体信号通路对 T 淋巴细胞激活的调节
- 批准号:
574984-2022 - 财政年份:2022
- 资助金额:
$ 19.49万 - 项目类别:
University Undergraduate Student Research Awards
Modulation of T lymphocyte Activation by ß2-adrenergic Receptor Signalling Pathways
α2-肾上腺素能受体信号通路对 T 淋巴细胞激活的调节
- 批准号:
574985-2022 - 财政年份:2022
- 资助金额:
$ 19.49万 - 项目类别:
University Undergraduate Student Research Awards
Modulation of T lymphocyte Activation by Ã2-adrenergic Receptor Signalling Pathways
α2-肾上腺素能受体信号通路对 T 淋巴细胞激活的调节
- 批准号:
574978-2022 - 财政年份:2022
- 资助金额:
$ 19.49万 - 项目类别:
University Undergraduate Student Research Awards
Investigating the cell-based activity of a new class of cytotoxic T-lymphocyte antigen-4 (CTLA-4) small molecule inhibitors
研究一类新型细胞毒性 T 淋巴细胞抗原 4 (CTLA-4) 小分子抑制剂的细胞活性
- 批准号:
444149 - 财政年份:2021
- 资助金额:
$ 19.49万 - 项目类别:
Operating Grants
Novel pathways in T lymphocyte differentiation and function
T 淋巴细胞分化和功能的新途径
- 批准号:
RGPIN-2015-05491 - 财政年份:2021
- 资助金额:
$ 19.49万 - 项目类别:
Discovery Grants Program - Individual
Modulation of T lymphocyte Activation by ß2-Adrenergic Receptor Signalling Pathways
通过 α2-肾上腺素能受体信号通路调节 T 淋巴细胞激活
- 批准号:
RGPIN-2019-06980 - 财政年份:2021
- 资助金额:
$ 19.49万 - 项目类别:
Discovery Grants Program - Individual