A modular toolkit of chemical probes for living cells

点击翻译按钮获取中文摘要

This project aims to develop a toolkit of fluorescent probes that can be assembled in a highly efficient ‘mix and match’ approach. Fluorescent probes allow unprecedented imaging of biological systems, but current probe design is inefficient due to a disconnection between those who make probes and those who use them. Novel fluorescent molecules will be designed and incorporated into new probes that are both selective for the chemical of interest and targeted to the relevant subcellular location. This will advance knowledge across synthetic chemistry, photo-physics and chemical biology, and expand the scope of chemical tools available for imaging, underpinning advances throughout cellular physiology.