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The effect of Pt binding to CTR1 on Cu homeostasis and cell phenotype

The effect of Pt binding to CTR1 on Cu homeostasis and cell phenotype
Pt 与 CTR1 结合对 Cu 稳态和细胞表型的影响
批准号:
DP150103369
负责人:
Prof Elizabeth New
金额:
$22.11万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 2017-12-31
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英文摘要
The copper transport protein CTR1 is commonly believed to transport active cisplatin (a platinum-based anticancer agent) into the cell, but this model is inconsistent with the chemical properties of platinum (Pt) and CTR1. The project aims to interrogate the interaction between CTR1 and Pt in cells by developing new chemical tools for the study of Pt species within cells. It will then study the effect of the CTR1-Pt interaction on copper homeostasis and cell phenotype. It is expected that the results will provide valuable information on the status of CTR1 and Pt following interaction, and reveal whether less toxic complexes are just as effective in decreasing cell malignancy as cisplatin itself.
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