TOTAL SURGICAL REPLACEMENT OF THE HUMAN HIP JOINT

人类髋关节的完全手术置换

• 批准号: 3154910
• 负责人: JORGE O GALANTE
• 金额: $ 16.68万
• 依托单位: RUSH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-05-01 至 1990-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3154910
• 关键词: alloys; arthroplasty; atomic absorption spectrometry; autologous transplantation; biological models; biomaterial interface interaction; biomaterials; bone prosthesis; bone regeneration; bone transplantation; calcium phosphate; chromium; cobalt; diffusion; dogs; electron probe spectrometry; electrostimulus; femur; hip prosthesis; homologous transplantation; hydroxyapatites; molybdenum; nickel; organometallic compounds; postoperative state; tissue /cell culture; titanium

This proposal is concerned with: (1) bone remodeling and associated structural changes in the proximal femur subsequent to implantation of porous coated femoral components in cementless total hip arthroplasty (THA) and (2) revision of failed cemented total hip arthroplasty with porous coated femoral components. The premise of bone ingrowth fixation is that the prosthesis will remain firmly anchored to the host bone indefinitely. Consequently, complications due to bone remodeling contitute one of the major long-term concerns. The location of the porous coating and the stiffness of the stem are two of the design parameters likely to influence the mechanical environment and, hence, remodeling of the proximal femur subsequent to cementless porous coated THA. A canine model will be used to provide data on the effect of these two parameters on bone remodeling and structural changes following cementless THA. Radiographic evidence of aseptic loosening has been reported to be as high as 40% in cemented revision of failed cemented THA. Cementless porous coated prosthesis are being used for revision arthroplasty, but it is not known if bone ingrowth actually occurs in this situation nor are the long-term effects on bone remodeing known. A canine revision model and a canine model of a gap at the interface between the host bone and the porous coating will be used to provide insight into the process of bone ingrowth, into the possibility of enhancing this process, and into cortical bone remodeling following cementless revision THA.

该提案涉及：（1）骨重塑及相关 植入后股骨近端的结构变化 非骨水泥全髋关节置换术 (THA) 中的多孔涂层股骨组件 (2) 失败的骨水泥型全髋关节置换术的多孔修复 涂层股骨组件。 骨长入固定的前提是假体将保留 无限期地牢固地固定在宿主骨上。 因此，并发症 由于骨重塑仍然是主要的长期问题之一。 这 多孔涂层的位置和杆的刚度是其中两个 可能影响机械环境的设计参数， 因此，在非骨水泥多孔治疗后对股骨近端进行重塑 涂层THA。 将使用犬类模型来提供有关效果的数据 这两个参数对骨重塑和结构变化的影响 非骨水泥 THA。 据报道，无菌松动的放射线证据高达 失败的骨水泥 THA 骨水泥修复中占 40%。 无水泥多孔 涂层假体已用于修复关节置换术，但并非如此 不知道在这种情况下是否确实发生了骨向内生长，也不知道 对骨重塑的长期影响是已知的。 犬修复模型和 宿主骨和多孔材料之间界面处间隙的犬模型 涂层将用于深入了解骨骼向内生长的过程， 探究增强这一过程的可能性，以及皮质骨 非骨水泥翻修 THA 后进行改造。