TOTAL SURGICAL REPLACEMENT OF THE HUMAN HIP JOINT

该建议针对使用多孔材料的骨骼固定的研究。 金属复合材料 具体而言，建议研究离子金属 释放，运输现象和相关的系统性影响，在多孔 铸造钴Chrome（ASTM F-75）的烧结粉末复合材料，锻造 钴镍铬钼（ASTM F-562）和Ti6 A14 V（ASTMF-136） 合金. 相关的有机金属配合物将被分离，并且它们的 使用体外成纤维细胞培养物评估毒性。 还打算 评价多孔烧结粉末钴的肿瘤诱导风险 Chrome复合材料（ASTM F-75）和锻造钴镍铬钼 (ASTM F-562，也称为MP35 N），以固体、粉末和多孔形式存在。 的 骨长入纤维钛复合材料的可能性 使用羟基磷灰石、磷酸三钙、氟化物、骨髓 含量、骨形态发生蛋白和直流电 将对刺激进行评估。 还建议比较 三种不同的钛多孔配置：纤维钛 复合材料作为全部或部分涂层，烧结钛球作为 一种全髋关节假体的固定方法。 骨骼的能力， 重塑及其对周围皮层的相关影响将是 评估。 半球形设计的髋臼假体也将 根据其骨长入的潜力进行评价， 固定

This proposal is directed to the study of skeletal fixation using porous metallic composites. Specifically, it is proposed to study the ion metal release, transport phenomenon, and related systemic effects in porous sintered powder composites of cast cobalt chrome (ASTM F-75), wrought cobalt nickel chromiun molybdenum (ASTM F-562), and Ti6A14V (ASTMF-136) alloys. The related organometallic complexes will be isolated and their toxicity assessed using in vitro fibroblast cultures. It is also intended to evaluate the tumor induction risk of porous sintered powder cobalt chrome composite (ASTM F-75) and wrought cobalt-nickel-chromiun-molybdenum (ASTM F-562 also known as MP35N) in solid, powder and porous form. The possibility of bone ingrowth enhancement into fiber titanium composites by the use of hydroxyapatites, tricalcium phosphate, fluorides, bone marrow contents, bone morphogenetic protein and direct current electrical stimulation will be evaluated. It is also proposed to compare the ability of three different titanium porous configurations: fiber titanium composite as a total or partial coating and sintered titanium spheres as a method of fixation of a total hip prosthesis. The ability of bone to remodel and their related effects on the surrounding cortex will be evaluated. An acetabular prosthesis of a hemispherical design will also be evaluated in terms of its potential for bone ingrowth as a means of fixation.