SYSTEMIC IMPLICATIONS OF TOTAL JOINT REPLACEMENT

全关节置换术的系统影响

• 批准号: 3159338
• 负责人: JORGE O GALANTE
• 金额: $ 18.58万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-05-01 至 1993-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3159338
• 关键词: aluminum oxide; atomic absorption spectrometry; cations; chromium; cobalt; hip prosthesis; human subject; joint prosthesis; longitudinal human study; manganese; nickel; surgery material /equipment; titanium; vanadium

Current clinical trends in total joint replacement (TJR) include implantation in younger patients and the use of non-cemented, porous coated metallic components which release greater amounts of corrosion products. In vitro and in vivo (animal and human) studies suggest a wide range of possible local and systemic biological sequelae to metallic release by TJRs. The proposed studies will address an important precursor to understanding the clinical significance of such effects: characterization of the release transport an storage of metallic moieties in patients with total hip replacements (THRs). This proposal involves three studies that will focus on distinct patient populations. The first study is a prospective, longitudinal study of metal ion release in patients undergoing primary THR with either a cementless titanium-base alloy prosthesis, a cementless cobalt-base alloy prosthesis or a cemented cobalt-base alloy prosthesis. The second study will examine metal ion release and local metal ion accumulation in patients undergoing revision THR for aseptic loosening of both cemented and cementless titanium-base alloy and cobalt-base alloy prosthesis. The third study will examine total body metal inventories in deceased individuals with cemented and cementless titanium-base alloy or cobalt-base alloy THRs. The primary analytical toll is Zeeman atomic absorption spectrophotometry (ZAAS). The results of theses studies will be critical in evaluating prospective risk to patients of the use of emerging total joint replacement technologies.

目前全关节置换术 (TJR) 的临床趋势包括 年轻患者的植入和非骨水泥的使用， 多孔涂层金属部件可释放大量 腐蚀产物。 体外和体内（动物和人类） 研究表明多种可能的局部和全身性 TJRs 金属释放的生物后遗症。 拟议的 研究将为理解 此类效应的临床意义：特征 患者体内金属部分的释放运输和储存 全髋关节置换术（THR）。 该提案涉及三项 研究将重点关注不同的患者群体。 第一个 研究是对金属离子释放的前瞻性、纵向研究 在接受初次 THR 治疗的患者中，无论是使用非骨水泥还是 钛基合金假体，一种非骨水泥钴基合金 假体或骨水泥钴基合金假体。 第二个 研究将检查金属离子释放和局部金属离子 接受无菌 THR 翻修的患者中的积累 骨水泥和非骨水泥钛基合金的松动 钴基合金假体。 第三项研究将检查总计 已故个体的身体金属库存 无水泥钛基合金或钴基合金 THR。 这 主要分析数据是塞曼原子吸收 分光光度法（ZAAS）。 这些研究的结果对于评估至关重要 使用新兴全关节对患者的潜在风险 替代技术。