TRABECULAR ARCHITECTURAL EFFECTS ON MATERIAL PROPERTIES

本项目的目的是调查 松质骨的形态和结构及其 力学性能在调查的第一阶段，我们 发展了量化三维形态的能力， 连接性和各向异性的骨小梁样本，利用独特的 微型计算机断层扫描仪此外，我们还通过实验 推导出正交模量和小梁之间的经验关系， 形态学 这项建议的具体目标是： 1.验证和评价一种新的三维形态学 和结构算法，我们已经指定的“配置 方法”。 2.为了实验性地开发一个更广义的结构函数 人类骨小梁的关系，以预测杨氏和 从形态学和建筑学的角度测量剪切模量。 3.通过实验确定小梁组织模量的变化， 年龄和解剖位置的函数。 4.利用微观结构方法， 研究骨小梁结构的最佳性， 对形态和结构因素的敏感性分析， 有助于机械完整性。 该项目将涉及测量骨小梁形态， 利用微计算机断层摄影扫描的连续级结构 材料测试和微结构材料测试。分析 程序将包括基于有限元的优化算法，沿着 同质化理论。 这些研究结果将为骨小梁 与结构优化相关的改造策略。这些信息 将支持继续努力了解 生理、机械或环境变化和骨小梁。

The objective of this project is to investigate the relationship between the morphologic and architectural configuration of trabecular bone and its mechanical properties. During the first phase of investigation, we have developed the capabilities of quantifying three-dimensional morphology, connectivity, and anisotropy of trabecular bone samples utilizing a unique microcomputed tomography scanner. In addition, we have experimentally derived an empirical relationship between orthogonal moduli and trabecular morphology. The specific aims of this proposal are: 1. To validate and evaluate the use of a new three-dimensional morphologic and structural algorithm which we have designated the "configuration method". 2. To experimentally develop a more generalized structure function relationship for human trabecular bone in order to predict the Young's and shear moduli from morphologic and architectural measures. 3. To experimentally determine the variation in trabecular tissue moduli as a function of age and anatomic location. 4. Utilize a microstructural approach to analytically and experimentally investigate the optimality of trabecular structure and perform a sensitivity analysis on the morphologic and architectural factors that contribute to mechanical integrity. The project will involve measuring the trabecular bone morphology and architecture utilizing microcomputed tomography scanning, continuum level materials testing, and microstructural materials testing. The analtyical procedures will include finite element based optimization algorithms along with of homogenization theory. The results of these studies will provide evidence for trabecular bone remodeling strategies related to structural optimization. This information will support continuing efforts towards understanding relationships between physiologic, mechanical, or environmental alterations and trabecular bone.