In-Vivo Micro computed Tomography system

描述(申请人提供)：本提案的目标是购买活体三维微型计算机断层扫描仪。该系统具有以45至75微米的分辨率数字化体内解剖结构(主要是骨骼)的三维形态和在某些情况下的微结构的能力。该系统将作为密歇根大学肌肉骨骼核心研究中心的核心技术在功能上运行。购买这一新系统的基本原理是基于在小动物模型中证明需要纵向测量组织或器官形态。体内3D MicroCT系统可以获得的数据使研究人员能够研究从骨质疏松症到成骨不全等骨骼疾病的相关机制，并评估包括组织工程结构在内的治疗方法的发现和发展。

DESCRIPTION (provided by applicant): The objective of this proposal is to purchase an in-vivo three-dimensional micro computed tomography scanner. The system has the capability of digitizing the three-dimensional morphology and in some cases micro-architecture of anatomic structures (dominantly skeletal) in-vivo, at a resolution between 45 and 75 microns. This system will functionally be operated as a Core technology within the Musculoskeletal Core Research Center at the University of Michigan. The principle rationale for the purchase of this new system is based on the demonstrated need for longitudinal measures of tissue or organ morphology in small animal models. The data that can be acquired by the in vivo 3D MicroCT system enables investigators to study mechanisms associated with skeletal diseases ranging from osteoporosis to osteogenesis imperfecta and evaluating the discovery and development of therapeutics including tissue engineered constructs.