High Resolution Specimen MicroCT System

描述（由申请人提供）：本提案的目的是购买一台三维微型计算机断层扫描仪。该系统具有数字化的三维结构的生物标本在5和100微米之间的分辨率的能力。该系统将基本上取代一个系统，该系统在过去17年中一直是密歇根大学核心设施运营的一部分，并支持130多名教师。购买这一新系统的主要理由是，大量资金充足的调查人员需要这一系统，而且这一系统在运作中出现了灾难性故障。通过3D Micro CT系统获得的数据使研究人员能够研究与骨骼疾病相关的机制，从年龄相关的骨质疏松症到遗传性疾病，如成骨不全，并评估治疗的潜力，包括组织工程构建和其他再生医学策略的发展。该系统的另一个重要用途是支持评估调节小动物骨骼功能的基本机制。

DESCRIPTION (provided by applicant): The objective of this proposal is to purchase a three-dimensional micro computed tomography scanner. The system has the capability of digitizing the three-dimensional architecture of biologic specimens at a resolution between 5 and 100 microns. This system will essentially replace a system that has been part of a Core facility operation at the University of Michigan for the past 17 years and has supported more than 130 faculty. The principal rationale for the purchase of this new system is based on needs of a large group of well funded investigators and the catastrophic failure that has occurred in the system that was in operation. The data which can be acquired by the 3D Micro CT system enables investigators to study mechanisms associated with skeletal diseases ranging from age associated osteoporosis to genetic diseases such as osteogenesis imperfecta and evaluating the potential for therapies including the development of tissue engineered constructs and other regenerative medicine strategies. An additional significant use of the system is in support of evaluating fundamental mechanisms regulating the function of the skeleton as modeled in small animals.