High Resolution Specimen MicroCT System

高分辨率标本 MicroCT 系统

• 批准号: 7211213
• 负责人: Steven A Goldstein
• 金额: $ 19.75万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7211213
• 关键词: Age; Animals; Architecture; Core Facility; Data; Development; Disease; Faculty; Failure; Funding; Hereditary Disease; Michigan; Modeling; Operative Surgical Procedures; Osteogenesis Imperfecta; Osteoporosis; Range; Regenerative Medicine; Research Personnel; Resolution; Skeletal system; Skeleton; Specimen; System; Tissue Engineering; Tomography, Computed, Scanners; Universities; base

DESCRIPTION (provided by applicant): The objective of this proposal is to purchase a three-dimensional micro computed tomography scanner. The system has the capability of digitizing the three-dimensional architecture of biologic specimens at a resolution between 5 and 100 microns. This system will essentially replace a system that has been part of a Core facility operation at the University of Michigan for the past 17 years and has supported more than 130 faculty. The principal rationale for the purchase of this new system is based on needs of a large group of well funded investigators and the catastrophic failure that has occurred in the system that was in operation. The data which can be acquired by the 3D Micro CT system enables investigators to study mechanisms associated with skeletal diseases ranging from age associated osteoporosis to genetic diseases such as osteogenesis imperfecta and evaluating the potential for therapies including the development of tissue engineered constructs and other regenerative medicine strategies. An additional significant use of the system is in support of evaluating fundamental mechanisms regulating the function of the skeleton as modeled in small animals.

描述(申请人提供)：本建议书的目标是购买一台三维微型计算机断层扫描仪。该系统具有以5到100微米的分辨率数字化生物标本的三维结构的能力。该系统将从根本上取代过去17年来一直是密歇根大学核心设施运营一部分的系统，并为130多名教职员工提供支持。购买这一新系统的主要理由是考虑到一大批资金充足的调查人员的需要，以及运行中的系统发生的灾难性故障。这些数据可以通过3D Micro CT系统获得，使研究人员能够研究与骨骼疾病相关的机制，从年龄相关性骨质疏松症到遗传性疾病，如成骨不全，并评估治疗的潜力，包括开发组织工程结构和其他再生医学策略。该系统的另一个重要用途是支持评价以小动物为模型的调节骨骼功能的基本机制。