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REGULATION OF INDIVIDUAL NEPHRON FILTRATION RATES

单个肾单位滤过率的调节

基本信息

批准号：
3151004
负责人：
WILLIAM H DANTZLER
金额：
$ 11.81万
依托单位：
UNIVERSITY OF ARIZONA
依托单位国家：
美国
项目类别：
财政年份：
1978
资助国家：
美国
起止时间：
1978-12-01 至 1988-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3151004
关键词：
glomerular filtration hormone regulation /control mechanism kidney circulation kidney disorder diagnosis kidney metabolism prolactin radiotracer renal tubular transport saluresis vasopressins

项目摘要

Our long-term objective is to increase our understanding of the regulation of nephron function by exploiting the unique renal structure of birds, the highly specialized renal structure of certain desert rodents, and the specialized transport properties of the nephrons of reptiles. The avian kidney has a population of nephrons resembling reptilian nephrons that function independently of each other, do not contribute directly to the concentrating mechanism, and can cease filtering altogether under some circumstances and a population of nephrons resembling mammalian nephrons that function together in the concentrating mechanism, do not normally cease filtering, but may alter their filtration rates. The kidneys of certain tiny desert rodents have juxtamedullary nephrons that are several times larger than the superficial cortical nephrons and a very long papilla and represent an intermediate state between the avian kidney and the more commonly studied mammalian kidneys. In contrast to mammalian nephrons, reptilian and avian nephrons secrete phosphate under the control of parathyroid hormone. Our primary goals under this broad objective involve studies of: 1) the regulation of nephron function, including the regulation of single nephron filtration rates (SNGFR) and tubular transport, in avian, desert rodent, and reptilian kidneys; 2) the relationship of single nephron function to the concentrating and dilut ng mechanism; and 3) the patterns and regulation of renal portal flow within the avian kidney. We are performing and plan to continue micropuncture and microperfusion (both in vivo and in vitro) studies of specific factors regulating SNGRFs (e.g., sodium, chloride, antidiuretic hormone, and distal tubule-glomerular feedback) and of factors influencing tubular transport, including phosphate transport (e.g., parathyroid hormone). We also plan micropuncture studies of loop of Henle function and the effects of alterations in SNGFR on this function. Electron microprobe analysis is being used to permit measurement of multiple inorganic ions in the tiny samples obtained. We also plan in vivo studies of avian renal portal blood flow patterns by silicone injection techniques and micropressure measurements and in vitro studies of specific factors (e.g., antidiuretic hormone) regulating the renal portal valve.

我们的长远目标是加深对规例的了解通过利用鸟类独特的肾脏结构，某些沙漠啮齿动物的高度专门化的肾脏结构，爬行动物肾单位的特殊运输特性。禽肾脏有一群类似于爬行动物肾单位的肾单位，相互独立地发挥作用，不直接对浓缩机制，并可以停止过滤完全根据一些环境和类似哺乳动物肾单位的肾单位群在集中机制中一起起作用的，通常不停止过滤，但可能会改变其过滤速率。的肾脏某些微小的沙漠啮齿动物有几个比表面皮质肾单位大10倍，乳头很长代表了鸟类肾脏和其他通常研究哺乳动物的肾脏。与哺乳动物的肾单位不同，爬行动物和鸟类的肾单位分泌磷酸盐，甲状旁腺激素在这个广泛的目标下，我们的主要目标包括：研究：1）肾单位功能的调节，包括调节单个肾单位滤过率（SNGFR）和肾小管运输，在鸟类，沙漠啮齿动物和爬行动物的肾脏; 2）单个肾单位功能与浓缩稀释的关系肾门脉血流的模式和调节鸟类的肾脏我们正在进行并计划继续进行显微穿刺，特定因子的微灌注（体内和体外）研究调节SNGRF（例如，钠、氯化物、抗利尿激素和远端肾小管-肾小球反馈）和影响肾小管转运的因素，包括磷酸盐转运（例如，甲状旁腺激素）。我们还计划 Henle袢功能的显微穿刺研究及 SNGFR的改变对这一功能的影响。电子探针分析是被用来允许测量多个无机离子在微小的获得的样品。我们还计划在体内研究禽肾门静脉血通过硅树脂注射技术和微压力的流动模式特定因素的测量和体外研究（例如，抗利尿激素）调节肾门脉瓣。