MECHANISM OF ACTION OF GROWTH HORMONE

生长激素的作用机制

• 批准号: 3151208
• 负责人: H M GOODMAN
• 金额: $ 21.45万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-05-01 至 1986-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3151208
• 关键词: adipose tissue; animal age group; cell free system; cell membrane; estradiol; glucose metabolism; homeostasis; hormone regulation /control mechanism; insulinlike factor; mitochondria; monoclonal antibody; protease inhibitor; pyruvate dehydrogenase; somatotropin; triiodothyronine

Using epididymal fat tissue and isolated cells, the studies are directed at uncovering the relationships of the various effects of growth to each other and to hormone binding. The events involved in the initial insulin-like response and the cellular processes that counter these effects will be explored in detail in an effort to determine whether the spectrum of growth hormone effects arise from a single unique interaction between the tissue and the hormone or from a series of independent actions. Ultimately, it is intended to relate these early rapid events to the overall process of growth promotion and regulation.

使用附睾脂肪组织和分离的细胞，这些研究旨在 揭示各种增长效应之间的关系， 激素结合。 初始胰岛素样反应中涉及的事件 以及对抗这些影响的细胞过程将被详细探讨 为了确定生长激素的作用范围是否 来自组织和激素之间的单一独特相互作用，或者来自 一系列独立的行动。 最终，它旨在将这些早期 快速事件的整体过程中的增长促进和调节。

项目成果

Turnover of growth hormone receptors in rat adipocytes.

大鼠脂肪细胞中生长激素受体的周转。

• DOI: 10.1210/endo-116-5-1796
• 发表时间: 1985
• 期刊: Endocrinology
• 影响因子: 4.8
• 作者: Gorin,E;Goodman,HM
• 通讯作者: Goodman,HM

Pituitary secretions related to adrenocorticotropic hormone induce sensitivity of adipose tissue to the insulin-like actions of growth hormone.

与促肾上腺皮质激素相关的垂体分泌物诱导脂肪组织对生长激素的胰岛素样作用的敏感性。

• DOI: 10.1159/000124719
• 发表时间: 1987
• 期刊: Neuroendocrinology
• 影响因子: 4.1
• 作者: Coiro,V;Goodman,HM
• 通讯作者: Goodman,HM

Covalent binding of growth hormone to surface receptors on rat adipocytes.

生长激素与大鼠脂肪细胞表面受体的共价结合。

• DOI: 10.1210/endo-114-4-1279
• 发表时间: 1984
• 期刊: Endocrinology
• 影响因子: 4.8
• 作者: Gorin,E;Goodman,HM
• 通讯作者: Goodman,HM

Binding and degradation of [125I]human growth hormone in rat adipocytes.

[125I]人生长激素在大鼠脂肪细胞中的结合和降解。

• DOI: 10.1210/endo-115-2-467
• 发表时间: 1984
• 期刊: Endocrinology
• 影响因子: 4.8
• 作者: Gorin,E;Grichting,G;Goodman,HM
• 通讯作者: Goodman,HM

Preparation and biological reactivity of polyiodinated human growth hormone.

多碘人生长激素的制备及其生物反应性。

• DOI: 10.1210/endo-113-6-2017
• 发表时间: 1983
• 期刊: Endocrinology
• 影响因子: 4.8
• 作者: Goodman,HM;Levy,LK
• 通讯作者: Levy,LK