MECHANISM OF ACTION OF GROWTH HORMONE

生长激素的作用机制

• 批准号: 3226352
• 负责人: H M GOODMAN
• 金额: $ 26.67万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-05-01 至 1991-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3226352
• 关键词: adipose tissue; animal age group; bioenergetics; calcium; cell free system; cell membrane; gene expression; glucose metabolism; growth factor; hormone binding protein; hormone receptor; hormone regulation /control mechanism; inositol phosphates; laboratory rat; membrane lipids; membrane proteins; monoclonal antibody; phospholipids; phosphorylation; protease inhibitor; radiotracer; second messengers; somatotropin; tissue /cell culture

This proposal is directed towards elucidation of the means by which growth hormone regulates metabolic pathways related to energy metabolism. Although it is the most abundant of the pituitary hormones and clearly influences growth, the essential nature of its effects on responsive tissues remains unknown. Although recent achievements in the production of synthetic growth hormone promise to relieve the shortage which has limited its use therapeutically, the poor understanding of its role in the devlopment of tissues and in the regulation of their metabolism may limit the effectiveness with which it may be administered to patients in the future. A better understanding of the function of this hormone in normal individuals is likely to improve the administration of other drugs, many of which are likely to affect many of the metabolic processes which are regulated by growth hormone as well as by other hormonal and metabolic factors. The specific aims of this proposal are: 1. To isolate and characterize the growth hormone receptors located on the surface of adipose tissue cells. 2. To investigate the possibility that intracellular concentrations of calcium and of metabolic intermediates derived from phospholipids may act as a second messenger. 3. To continue investigations of several of the metabolic targets of growth hormone action and how they are related to one another.

这一建议旨在阐明增长的手段， 激素调节与能量代谢有关的代谢途径。 虽然它是最丰富的垂体激素， 影响增长，其对响应的影响的本质 组织仍然未知。 虽然最近在生产方面取得的成就， 合成生长激素有望缓解短缺， 它的治疗用途，对它在治疗中的作用的理解不足， 组织的发育及其代谢的调节可能会限制 它可以被给予患者的有效性， 未来 更好地了解这种激素在正常情况下的功能 个人可能会改善其他药物的管理，许多 这可能会影响许多代谢过程， 由生长激素以及其他激素和代谢调节 因素 这项建议的具体目标是： 1.分离并表征位于细胞表面的生长激素受体 脂肪组织细胞表面。 2.为了研究细胞内浓度的 钙和来自磷脂的代谢中间体可能起作用 作为第二信使。 3.继续研究几个生长代谢靶点 激素作用以及它们之间的关系。