Sub-Cellular OCT Imaging

亚细胞 OCT 成像

• 批准号: BB/J021571/1
• 负责人: Richard Hogg
• 金额: $ 16.03万
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FJ021571%2F1
• 关键词: Sub; Cellular; OCT; Imaging

Optical coherence tomography (OCT) allows the 3D imaging of skin tissue on a depth scale of ~1-2mm with resolution ~10um. It has been described as an optical analog of ultrasound imaging and offers significantly better resolution than MRI and ultrasound. It has already gained clinical acceptance in ophthalmology and is emerging into other fields such as oncology, monitoring wound healing, cardiology, and guided surgery. The advantages of OCT include:- Video rate images of sub-surface morphology at resolutions ~100 better than ultrasound and voxel rates ~1000 higher than microscopy. Label-free imaging of the sample (in vivo or in vitro).Non-ionizing radiation. Non-contactEndoscopicOCT is ideal for imaging 1~2mm below the surface in biological tissue. Our project is concerned with the development of a prototype swept laser source with 200 - 300 nm sweep range providing sub cellular resolution. We will develop the laser system and trial it in an OCT imagining system.

光学相干断层扫描（OCT）允许在~1- 2 mm的深度尺度上对皮肤组织进行3D成像，分辨率为~ 10 um。它被描述为超声成像的光学模拟，并提供比MRI和超声更好的分辨率。它已经在眼科获得了临床认可，并正在进入其他领域，如肿瘤学，监测伤口愈合，心脏病学和引导手术。OCT的优势包括：-亚表面形态的视频速率图像，分辨率比超声高约100，体素速率比显微镜高约1000。样品的无标记成像（体内或体外）。非电离辐射。非接触式内窥镜OCT是生物组织表面以下1~ 2 mm成像的理想选择。我们的项目是与一个原型扫描激光源的发展与200 - 300 nm的扫描范围提供亚细胞的分辨率。我们将开发激光系统，并在OCT成像系统中试用。